Zinc Finger Design AI Tool Opens Door to Large-Scale Gene Therapies

ZF editing can both change and control genes. Among the most abundant protein structures in the human body, ZFs can guide DNA repair by grabbing onto scissor-like enzymes and directing them to cut faulty segments out of the code.

Similarly, ZFs can also hook onto transcription factors and pull them toward a gene segment in need of regulation. By customizing these instructions, genetic engineers can tailor any gene’s activity.


One of schizophrenia candidate genes is ZNF804A, a zinc finger protein