Interesting article. Are they talking about modifying bacterial 
DNA or human DNA? I didn’t read the whole thing
It’s in human cells, but just cultured cells, so in a petri dish. The next step is to use it in animals.
Do we have any clear genetic targets for sz? Any genes or clusters of genes where we know how they work? Like a target they can make a decent approximation at how the therapy will effect the brain behavior etc?
There’s at least hundreds of genetic targets.
I have read a couple of rodent studies where they applied gene therapy and had partial reversal of behavioral/cognitive symptoms in adulthood.
This is one paper on it.
https://www.nature.com/articles/tp201719
The mice were
ILN-selective conditional knockout (cKO) mice for NR1, which encodes an essential NMDAR subunit.
Notably, restoring NMDARs in the adult ILN rescued some of the behavioral abnormalities. These findings suggest that NMDAR dysfunction in the ILN contributes to the pathophysiology of schizophrenia-related disorders. Furthermore, the reversal of inherent schizophrenia-like phenotypes in the adult mutant mice supports that ILN is a potential target site for a therapeutic strategy.
I think the authors here were validating the target of the ILN for medications, not necessarily gene therapy, but they did it with gene therapy.
This one is on ErbB4 knockout mice:
I’ll just leave this here too: