Before trying a new supplement, talk to your psychiatrist first because they will know safety profiles the best; also interactions with other meds is crucial.
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Doc won’t let me go near this one. My liver never came back all the way from when I drank. Even protein supplements stressed it.
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I’ve done some reading on Glycine, and it sounds very promising. It does more than help schizophrenia, it seems to be a fundamental building block of a happier, healthier body and mind
I’m trying it out of this week
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I just ordered some glycine online, it should arrive in about a week. I wonder if it will help me sleep, the research I have done looks good, but I’ve tried things in the past only to be let down.
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Me personally, I started with one capsule (1000mg) and since it’s half life is ~4 hours, and after 5-6 HL the substance is 97-98% cleared/gone, I have broken it down to one capsule (1000mg) every 16 hours. I read on NCBI that not very much crosses the Blood Brain Barrier (I’ll look up what the facts are on that momentarily), therefore, the brain doesn’t SEE 1000mg, probably a lot less. So the goal is to “bathe” the NMDA receptors in glycine being in the synapse AND Sarcosine is a glycine transporter1 inhibitor (It’s a reuptake channel, so Sarcosine acts on glycine just like Zoloft inhibits the reuptake of serotonin/5HT).
Combine blocking reuptake of glycine AND exogenously (from outside the body) adding glycine which gets into the synapse = the cells can have better functioning synaptogenesis (birth of new neurons) and increased synaptic plasticity (stronger connections).
Fun fact, with schizophrenia, we lose a lot of GABA signaling that calms our brains right? NMDA 2A receptors are undetectable on 50-73% of GABA neurons, therefore, we need to find a solution to getting neurons to heal and be strong rather than damaged in schizophrenia; glycine and Sarcosine CAN BE THAT SOLUTION!
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I don’t know how it will help with sleep if it does not cross the blood brain barrier but I am going to give it a try.
I read it took between 3-5 grams to help with sleep in scientific studies. I bought 500mg pills, so I will have to take between 6 and 10 of them. I’ll start low and work up from there.
I just got an email and they have shipped. I bought them from iherb,com
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Came across this. Glycine helps with negative symptoms in schizophrenia too. Maybe that is why you feel better. By increasing serotonin it also helps with sleep.
I’ve been taking Glycine for about a week, and I have to say my head feels much clearer already. Nothing else has changed, so there’s nothing else I can contribute this to
I’m going to stick it out for 3 months and reassess, but so far it seems to be working quite well
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@Cragger What dosage are you taking, and what time of the day do you take it?
I took 4000mg last night and fell to sleep fine (along with 1.5mg of clonazepam) but I woke up after 5 hours cause I had to pee and couldn’t get back to sleep.
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@Headspark I take 1000 mg, three times a day. Breakfast dinner and bedtime. It doesn’t seem to make me sleepy at the time, but I do seem to get a better sleep for some reason. The main thing I noticed, is Clarity of mind
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Okay, cool. I took 4000mg last night, and another 1000mg today around noon.
I think tonight I’ll try 3000mg before bed then 1000mg twice a day during the day tomorrow and see how i feel. I am still int he experimental stage.
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Yeah, me too. That’s why I’m playing it safe for now. From what I’ve read, it mixes quite well with antipsychotics though
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Yeah, in the last 24 hours I have taken 5000mg of glycine and feel fine so far. I’m on Lurasidone 60mg as my antipsychotic. I posted an article a few posts up about how its good for sleep and schizophrenia. I am also taking l-theanine, 100mg every 4-5 hours every day. I’ve read both are good for schizophrenics.
So far I feel pretty good and haven’t experienced anything negative.
I usually fall to sleep fine but if I wake up after 5 hours or so I can’t get back to sleep for some reason.
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I was as reading up on Glycine and came across this (Glycine Naturally Aids Healthy Sleep) and this (Glycine Can Help with Metabolic Disorders and Diabetes) and this (Mental Health and Glycine)
If all this is true I can kill 3 birds with 1 stone. My sleep, my diabetes and my schizophrenia.
I have felt better the last few days.
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This is affordable with 300 capsules. Also I’m ordering powder form bulksupplements from amazon.
I just started glycine a few weeks ago, and I do feel it has improved my state of mind. I can’t put it down to anything else so it must be working
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8 grams of glycine during the day works for my internal and external voices almost 100%.
Just have to be careful to take minimal amount of caffeine in the morning.
Maybe I can lower the amount since I’m on invega 234mg.
I guess its the central nervous system suppression that does the trick.
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My eyelid on my right eye twitches sometimes, it doesn’t hurt but its annoying, it’s subtle but it bugs me. I think it is caused from being on AP’s for almost 20 years. Glycine has stopped my eye lid from twitching too which is great, I wasn’t expecting that.
I now take 10000mg (10 grams) 1/2 hour before bed, about 1 teaspoon I think it works out too.
I bought the 1lbs bottle of NOW Glycine powder from iherb,com
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Glycine is pretty effective addon for voices even at 10 grams a day divided for 5 grams in the morning and 5g before bed.
My internals are pretty much gone and mind reading is almost gone.
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I read an article that said to be effective for schizophrenia they gave the patients 60 grams a day.
But everyone is different. I am sticking with 10 grams for now.
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