Has everyone covered all bases in the supplement world?

TheBest · January 27, 2018, 9:36pm

What stones left unturned do you have? Have you tried all the supplements on schizophreniacom?

My Grades

NAC- A
Sarcosine- C
D Serine- ?
Melatonin- C
Omega 3- B
D Alanine- ?
B Vitamins- C

anon1571434 · January 27, 2018, 9:50pm

Sarcosine did not help me but it tasted nice.

TheBest · January 27, 2018, 9:51pm

Sarcosine helped me the first 5 minutes I took it. Then really I don’t notice much.

everhopeful · January 27, 2018, 10:00pm

I can’t see D-alanine on iherb. There’s some positive research for it though.

ncbi.nlm.nih.gov

D-alanine added to antipsychotics for the treatment of schizophrenia.

GE Tsai, P Yang, YC Chang and MY Chong, Biological psychiatry, Feb 2006 01

Hypofunction of the N-methyl-d-aspartate (NMDA) subtype glutamate receptor had been implicated in the pathophysiology of schizophrenia. Treatment with D-serine, glycine, endogenous full agonists of the glycine site of the NMDA receptor (NMDA-glycine site), D-cycloserine, a partial agonist, or sarcosine, a glycine transporter-1 inhibitor, improves the symptoms of schizophrenia. D-alanine is another endogenous agonist of the NMDA-glycine site that might have beneficial effects on schizophrenia.Thirty-two schizophrenic patients enrolled in a 6-week double-blind, placebo-controlled trial of D-alanine (100 mg/kg/day), which was added to their stable antipsychotic regimens. Measures of clinical efficacy and side effects were determined every other week.Patint who received D-alanine treatment revealed significant reductions in their Clinical Global Impression Scale and Positive and Negative Syndrome Scale (PANSS) total scores. The Scale for the Assessment of Negative Symptoms and PANSS subscores of positive and cognitive symptoms were improved. D-alanine was well tolerated, and no significant side effect was noted.The significant improvement with the D-alanine further supports the hypothesis of hypofunction of NMDA neurotransmission in schizophrenia and strengthens the proof of the principle that NMDA-enhancing treatment is a promising approach for the pharmacotherapy of schizophrenia.

TheBest · January 27, 2018, 10:01pm

What scares me about D-Alanine is that it makes you gain weight. I guess if it works it works.

everhopeful · January 27, 2018, 10:01pm

Ah. I don’t need that !!

TheBest · January 27, 2018, 10:02pm

I can’t even find D Alanine on Google shopping.

TheBest · January 27, 2018, 10:12pm

I just read that Glycine is similar to D Alanine. Maybe that’s what people buy.

anon57786250 · January 27, 2018, 10:14pm

From what I"ve been reading, NMDA/Glutathione receptors play a big role in schizophrenia.

everhopeful · January 27, 2018, 10:14pm

I tried glycine. I just got nauseous on it. I couldn’t take much of it.

TheBest · January 27, 2018, 10:15pm

You never know what works for you until you try it.

TheBest · January 27, 2018, 10:16pm

Isn’t Glycine supposed to help you sleep?

everhopeful · January 27, 2018, 10:18pm

Ive no idea. It was supoosed to be good for negative symptoms. But I couldn’t tolerate it.

ncbi.nlm.nih.gov

Adjunctive high-dose glycine in the treatment of schizophrenia.

DC Javitt, G Silipo, A Cienfuegos, AM Shelley, N Bark, M Park, JP Lindenmayer, R Suckow and SR Zukin, The international journal of neuropsychopharmacology, Dec 2001

Glycine is an agonist at brain N-methyl-D-aspartate receptors and crosses the blood-brain barrier following high-dose oral administration. In a previous study, significant improvements in negative and cognitive symptoms were observed in a group of 21 schizophrenic patients receiving high-dose glycine in addition to antipsychotic treatment. This study evaluated the degree to which symptom improvements might be related to alterations in antipsychotic drug levels in an additional group of 12 subjects. Glycine treatment was associated with an 8-fold increase in serum glycine levels, similar to that observed previously. A significant 34% reduction in negative symptoms was observed during glycine treatment. Serum antipsychotic levels were not significantly altered. Significant clinical effects were observed despite the fact that the majority of subjects were receiving atypical antipsychotics (clozapine or olanzapine). As in earlier studies, improvement persisted following glycine discontinuation.

insidemind · January 27, 2018, 10:21pm

Sarcosine is the best one mentioned, followed by NAC.

TheBest · January 27, 2018, 10:22pm

So you would give Sarcosine an A if you were to grade it? And a B for NAC?

insidemind · January 27, 2018, 10:22pm

Yes. I would. Sarcosine made me smarter. Helped with negative symptoms.

TheBest · January 27, 2018, 10:24pm

How long did it take to make you smarter? I instantly notice NAC helping my symptoms.

insidemind · January 27, 2018, 10:25pm

Maybe a few weeks. I don’t know. I instantly felt stimulated though.

TheBest · January 27, 2018, 10:58pm

A’s: (amazing)

NAC
Metamucil

B’s: (above average)

Phosphatidyl Serine
Ashwagandha
Bacopa
Gotu Kola
Omega 3
L Theanine
Emergen C Packets

C’s (average)

Rosemary
Melatonin
Turmeric
Pantothenic Acid
B-2
Vitamin D
Vitamin E
Folic Acid
B-1
Melissa
Sarcosine
Asian Ginseng

What I’m trying soon:

CoQ10
Amino Focus

TheBest · January 27, 2018, 11:05pm

Anyone find an A supplement?

Topic		Replies	Views
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D-serine,sarcosine,NAC supplement experiences ?! Medications	8	4398	January 22, 2015
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Has everyone covered all bases in the supplement world?

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