Will there ever be a cure for sz?

One can hope. It doesn’t seem like a cure is a priority though, but maybe I’m just pessimistic.

I hope so, I think more and more that schizophrenia is related to synaptic loss. It’s only since 2016 that we can mesure in vivo synaptic density in people alive. And it correlates with the study post mortem that schizophrenics have lower synaptic density than healthy control. In mice, when they manipulate them for having less synaptic density, there is an increase in dopamine in the striatum. Plus there is a ratio of 4 men with schizophrenia for 1 woman with schizophrenia and there is a study that says estradiol (a feminine hormone) can protect against glutamatergic synapses loss and could explain why women are less impacted by schizophrenia than men. SPG302 in clinical trials is supposed to rescue this synapse loss, and maybe JRT (an LSD analog without trip supposed to create new synapses for schizophrenics) could help alleviate symptoms.
These are recent studies (2023, 2022 and 2020).

https://www.nature.com/articles/s41380-023-02043-w

https://www.biologicalpsychiatryjournal.com/article/S0006-3223(22)01366-X/fulltext

https://www.nature.com/articles/s41398-020-0682-4

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Maybe in 300 years or so.

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I think everyone in here has such longtime lines because of how helpless being a psychiatric patient makes you feel. Baring some kind of catastrophe I’m certain it won’t be longer than 30 years and that’s being extremely conservative. It’ll probably happen much sooner. The thing about schizophrenia is it isn’t one single illness. There are probably at least a dozen subtypes, some of which will be much easier to fix than others. Every week we get news about how there finding bio markers in the blood or how a new inflammatory mechanism has been implicated. We’re already seeing people achieving remission with things like keto and evenamide. I mean has no one seen the evenamide data? 25% of trs achieved remission. Lots of things are happening. And it’ll only get faster and cheaper to make this kind of progress.

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maybe technologically but i doubt any medication can physiologically and neurologically cure brain and body dysfunction

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maybe theyll have like an ai neuralink like device that detects stress and abnormalities and alters and releases/ blocks certain neurotransmitters

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I would put more emphasis on preventing schizophrenia instead of curing schizophrenia. About 75% of people with schizophrenia experienced a prodrome (a/k/a prodromal) phase before their first psychotic break, so if we can increase awareness, detection and intervention, we may be able to prevent, to some degree or another, those people from progressing to schizophrenia.

It will be easier said than done because the symptoms of schizophrenia often mask other illnesses.

Awareness, early detection and early intervention have cured illnesses that were once thought to be uncurable. Cervical cancer, certain thyroid cancers, testicular cancer, skin cancer (melanoma), --even rabies–are curable through early detection and intervention.

All of that said, I don’t know if there will ever be a cure for schizophrenia.

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I think the only cure for schz is death. I think I’ll prefer to just live and deal with the symptoms. I have good days and bad days.

Whoever cures it, will get a Nobel prize :trophy:. But the pharma industry will lose billions and billions.

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Well, they haven’t invented better medicines overall compared to the old ones…. or else everybody would be talking the better medicines. I don’t think they will find a cure for it.

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Honestly, the newer antipsychotics may be safer but probably not more effective than the older APs.
There may be a cure way down the road but curing SZ is not high on the priority list, unfortunately.

IF the human race survives long enough, yes, there will likely be a cure for sz some point. Very little is insurmountable by science eventually.

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on a related note, very little is unmountable by @shutterbug

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Maggie still hasn’t forgiven me, huh.

:face_holding_back_tears:

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I don’t believe schizophrenia is actually one disease with one particular cause.

I think it’s multiple diseases with multiple causes because of how differently people experience it.

Because of that, I believe we need multiple cures for it.

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The cost of schizophrenia is very high too… It’s estimated to be 300 billions per year…

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I hope so. But taking the right medication helps and having a good support system. :slightly_smiling_face:

Yes, I believe you’re on to something. I’ve studied Beth Steven work a bit. And she asserts that synaptic pruning is a source of problems for the development of the brain. This leads to schizophrenia. That’s kind of theory in a nut shell. Of course it’s much more complicated than that. Have you heard of her Sebastion?

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No but I will read what she says ! Thanks !

Excellent! Pretty insightful stuff as far as I can tell.