My psychiatrist is not available for some time.
I am thinking particularly about a dose that has no dopaminergic, histaminergic, adrenergic, etc., but only blocks serotonin receptors, particularly the 5ht2a?
I know a very low dose is prescribed some times for non-psychotic disorders where the 5ht2a receptor is dysfunctional (affective disorders, autism)… but this says nothing about what else it does at those small dosages.
I’m guessing 0.25mg but I could be wrong.
Wait to speak to your psychiatrist.
Risperidone seems to have a very high affinity as an 5ht2a antagonist, but as @Wave said, consult with your pdoc:
Do you find that this dose does anything for intrusive thinking (or over thinking) and all the other ■■■■ caused by the 5ht2a receptor?
I took 6mg for some time but not sure if it did anything for this issue, my memory of the period I took it is foggy. At least I know I couldn’t think at all, or so it felt.
Risperidone does something for me, acting as an Antipsychotic at doses no lower than 2mg.
If I go lower than 2mg, I end up in the Hospital.
I suggest that you talk it over with your psychiatrist.
I will when I can. Do you suffer from intrusive thoughts or “overthinking,” like you can’t stop thinking about things obsessively? – when you are not medicated? In other words, do you find risperidone helps with this?
I suffer with OCD - severe Obsessions and intrusive thinking.
Honestly I think that Risperidone is worsening my OCD but as you know everyone reacts to these meds differently.
Why, Can’t you go on an Antidepressant?
Too much science don’t understand lol. All I know this receptor is for memory or something. So is respirdal blocking this or fixing, or worsening this recepter?
That’s very interesting, I would love to understand how that is since the usual jargon is that intrusive or excessive thinking is caused by dopamine excess–it’s not, not everything is dopamine induced. Maybe this is glutamate related… but the 5ht2a receptor is extremely complex it seems because it interacts with so many things… or maybe it’s just me.
I believe that taking an SSRI (if thats what you mean) to fix excessive serotonin activity is the dumbest choice… but this is not medical advice bla bla bla. It’s like you’ve cut your finger by accident and then the doctor recommends cutting your finger some more to desensitize the nerves in your finger and cause a feedback effect… just stupid. We need an SSRE - a reuptake enhancer… I am already extremely sensitive to serotonin, just a little serotonin and I tend to get very irritable and fatigued and so on.
I have severe obsessiveness and excessive thinking as well.
I read on some other forum by multiple users of paradoxical effects from mirtazapine, the effects associated with increased 5ht2a activity, like irritability, moodiness, ocd, etc. Not sure if those reports are true but maybe 5ht2a antagonism can produce paradoxical effects in this regard and thus explain your experiences
I’m not sure even the scientists would know what you were talking about. All of the talk about receptors is just theory, it’s still not an exact science.
I have been on risperidone, and it did not affect me much serotonin wise.
I can’t tolerate risperidone for more than 5 months, because of akathesia, especially restless legs.
The only antipsychotics I can tolerate are chlorpromazine or olanzapine, but they both make me fat, and I need to take an ssri with them to stop me feeling suicidal.
I sometimes compare the negative symptoms of schizophrenia with depression, but the drugs they use to treat each are completely opposite.
I have more problems with intrusive thoughts, rather than hearing voices.
