What does blocking dopamine mean?

DX'd - Other
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Can someone explain:

What is it?
What differenciates it from normal population?
Side effects of just blocking dopamine?

Thanks!

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APs block d2 dopamine receptors. Its known that high dopamine in the dorsal striatum in the brain causes sz. Blocking these receptors can make negative and cognitive symptoms worse.

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Okay, thanks @anon67051439

You said in another post that they block around 70-80% of dopamine.

Is this a lot compared to normal population?
What are the common negative/cognitive symptons for you

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I just want to get off meds asap… not possible as long as I still smoke weed.

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What meds are you on

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Abilify 15, i was taking sertraline not so long ago. Want to get into trt

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I ■■■■■■ up my first abilify 10 taking coke, mdma and speed. Now my doctor doesn’t want to try to reduce it.

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Does Abilify effect prolactin

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No clue. I just know my bloodwork will show that.

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yes its a lot, weed does make sz worse. if you want to try off meds I would ask your Dr. Did you ever try off meds before without getting psychotic?

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Abilify is not so bad, its a partial agonist so it doesn’t block as much dopamine as other APs like risperidone

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No. The only chance and I ■■■■■■ it up. I have a very good friend. We usually meet at cannabis coffee couple times a week. He just comes to town to buy some hash, so we meet. It will be hard for me to leave weed because of socialization.

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You can socialize with them, just don’t use weed. If you can’t just find new friends that don’t use weed.

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I have my hopes on beeing eligible for trt…

I will make some drastic changes on my life if it becomes a reality.

If not, I don’t really care

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It means the bouncer won’t let it into the club.

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@anon67051439
I’m really low on mood and energy all day long. My fitness goals are too difficult to bare in my current state. My sex drive fluctuates from 2 weeks good 2 months bad. My cognition skills are through the floor, I cannot do any mentally challenging activity.

I guess a lot of people here feel the same. But I don’t see the point of continuing like this.

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Tbh that’s an accurate depiction of how I feel…

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I’m feeling under the weather this morning. It’s more like I was in the club, but the bouncer tossed me out without bothering to open the door first. Ow.

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Honestly stopping the meds might not help much, i think most of the negative and cognitive symptoms are from the illness itself and not the meds. When I stopped the meds for 2yrs my negatives improved a bit but thats all, I was no way near my presz functional lvl.

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Id tell your doctor this. There are a lot of meds out there. A lot of times people are happy just to get the relief meds can bring. I can’t say much cause I was on invega for 14 years. I got off it a lot and wanted to go med free route for a long time. A lot of people feel this way. My psychosis was too much though. I’m on perphenazine and don’t hear voices anymore and the side effects are hardly noticeable. I was there though. I got lucky with this med.

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