What causes people to get sick from schizophrenia?

[thomas]

you must have genetic predisposition, and environmental triggers. facts.

[anon9798425]

@doing-fine-thanks

My mother describes her pregnancy with me as practically ideal, while my sister was a difficult pregnancy. I developed schizoaffective disorder, and my sister didn’t. Who knows?

Well we’re not just talking about flus and alcohol, obviously. It could be something she didn’t know about.

[rogueone]

There’s a link and it probably is in utereo!

Some weird spikes. After world war 2 in Holland there was a spike that may have been due to starvation. It’s not much to hang a hat upon but @anon9798425 is on the money. It’s stuff you have no control over as a parent. It’s just a genetic flaw that gets hit by an environmental trigger.

Good, bad, indifferent. It results in the same thing!

[77nick77]

I think the Potato Gods have something to do with it.

[doing-fine-thanks]

@anon9798425

Well we’re not just talking about flus and alcohol, obviously. It could be something she didn’t know about.

Like what? She wasn’t in any form of distress whatsoever, and my birth was probably one of the few that would be considered “non-traumatic.”

[anon73478309]

A famous psychiatry in my country says sz doesnt exist. He says EVERYONE can develop psychosis under the “right” circumstances. 20% of people, he argues, have at least one psychotic symptom in their lives. Most recover. He says 3% will go on to develop a psychotic syndrome, milder or worse.

[Wave]

It’s mainly genetics but stressors and drug use can exacerbate the process as well.

For me it was genetics, stressful environment and use of a hallucinogenic that triggered me into psychosis land.

[anon9798425]

@doing-fine-thanks

Like what? She wasn’t in any form of distress whatsoever, and my birth was probably one of the few that would be considered “non-traumatic.”

One hypothesis that he mentioned was that antibodies from previous infections can unknowingly attack the fetus. And beyond that, teratogens can be all kinds of “invisible” substances. Even stress can be considered a teratogen.

[BrianTex]

Probably destiny

[anon9798425]

@anon73478309

A famous psychiatry in my country says sz doesnt exist. He says EVERYONE can develop psychosis under the “right” circumstances.

Very few people who undergo severely traumatic events go on to develop sz, and about 80% of the differences between people in terms of having vs not having sz are due to heritable factors. That’s a very strange statement considering what we know about sz. And diagnostically, sz and psychosis are not the same.

[anon60523054]

I don’t really know what causes it but my uncle has it too, and I had troubles even as a child.

[anon73478309]

Hey, one alinea is a bit short to convey his full argument. He doesnt say there is no genetic component! But, if i understood him right:

1. He wants to get rid of the term schizophrenia. He uses psychotic syndrome here, which can vary from mild to severe. I personally also wonder if there is such a clear demarkation line between non-sz and sz: even after 9 years they are still not sure whether to label me with sz.
2. He argues that psychotic symptoms are a very common occurence, with all sorts of causes and expressions. Sure, some people might be more sensitive and some less sensitive, but f.e. 25% of ptsd sufferers have psychosis.

It helps me personally to see it in this way.

I wonder btw how you come to 80%? I thought i read even in identical twins there is “only” a chance of 50% to develop sz if the other has it? And they have shared the pregnancy and environment too. Maybe im wrong though!

[anon73478309]

Depending on the severity of trauma, people can even have a 50 times increased risk of sz. That is a lot. https://psychcentral.com/news/2012/04/20/childhood-trauma-linked-to-schizophrenia/37610.html

[anon9798425]

@anon73478309

I wonder btw how you come to 80%? I thought i read even in identical twins there is “only” a chance of 50% to develop sz if the other has it? And they have shared the pregnancy and environment too. Maybe im wrong though!

You’re not wrong about the concordance rate, but concordance rate is not the same as heritability. The heritability has been researched many, many times and averages around 0.80.

[anon73478309]

Ah okay! I couldnt precisely remember, just the 50%. I understand!

[anon9798425]

@anon73478309

Depending on the severity of trauma, people can even have a 50 times increased risk of sz. That is a lot. https://psychcentral.com/news/2012/04/20/childhood-trauma-linked-to-schizophrenia/37610.html

Childhood trauma is a well-known risk factor, yes, but adulthood trauma not so much. Also, and especially with childhood trauma, there is not a clear separation between environmental effects and genetic effects, due to gene-environment correlations and interactions.

[anon73478309]

Understand! 151515

[doing-fine-thanks]

@anon9798425

One hypothesis that he mentioned was that antibodies from previous infections can unknowingly attack the fetus. And beyond that, teratogens can be all kinds of “invisible” substances. Even stress can be considered a teratogen.

Anything is possible. My case is kind of unusual. I was diagnosed with “Psychotic Disorder: Not Otherwise Specified (NOS)” and was only given the “schizoaffective disorder” diagnosis for insurance coding purposes. My symptoms of mental illness (and physical illnesses as well) typically don’t follow set patterns.

[TomCat]

For me it was severe stress. Unfortunately once you get it it’s not reversible so it doesn’t really matter how you got it. It’s not going away.

[PinCushion]

buried injuries, auditory and physical.