Take more Vitamin D and B-12? Cheap experiment, anyway.
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i sun bathe for vitamin d all summer long
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i have heard that before and have that on my mental list to start taking
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My Vitamin D levels are always low. I don’t get enough sunlight and I don’t drink milk. My doctor prescribed Vitamin D for me a few years ago and I was taking it for a while. I didn’t notice much of a difference and eventually stopped taking it.
I tend to get put on the 50000 IU D pills once a year (vitamin D is fat soluble, so don’t try this without dr prescription!) and I can feel the difference almost immediately. I get that pleasant wrung out feeling, like I’ve been crying for hours. I don’t know what the long term effects really are, but short term is very helpful for me.
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I got my vitamin D levels checked by my GP - they are low - so now I am taking extra Vitamin D3 everyday.
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http://www.snpedia.com/index.php/Rs2060793 AA-lower serum levels of vitamin D according to Promethease.
http://www.snpedia.com/index.php/Rs602662 AA- higher vitamin B12 levels according to Promethease.
Went to the link. Couldn’t find the research. ???
According to what it says on my Promethease report: Levels of 25-hydroxyvitamin D in familial longevity: the Leiden Longevity Study. Concluded that familial longevity was associated with a lower vitamin D levels and a lower frequency of the allelic variation in the CYP2R1 gene. Genome-wide association study of circulating vitamin D levels. This SNP is part of CYP2R1, which encodes a key C-25 hydroxylase that converts vitamin D3 to an active vitamin D receptor ligand. This SNP, along with rs2282679, rs3829251, and rs6599638 accounted for 2.8% of the variance in circulating vitamin D levels. [GWAS:Vitamin D levels]
According to the Promethease report:
Higher vitamin B12 levels The reduced activity of the FUT2 enzyme with the A allele may decrease susceptibility to bacterial infection and indirectly lower the risk of vitamin B12 malabsorption, thereby resulting in higher vitamin B12 concentrations in A allele carriers.
[PharmGKB:Non-Curated GWAS results: Genome-wide Association Study of Vitamin B6, Vitamin B12, Folate, and Homocysteine Blood Concentrations. (Initial Sample Size: 2,934 individuals; Replication Sample Size: 686 individuals); (Region: 19q13.33; Reported Gene(s): FUT2; Risk Allele: rs602662-A); (p-value= 3E-20).This variant is associated with Folate pathway vitamins.] [OMIM:VITAMIN B12 PLASMA LEVEL QUANTITATIVE TRAIT LOCUS 1; B12QTL1] [GWAS:Folate pathway vitamins]
Note Parkinson and Prostate. My half aunt had Parkinsons and my father has had trouble with his prostate, Schizophrenia appears in the tag cloud as does bipolar to a lesser degree.
I may well be wrong, but the genetic pathway with respect to V-B seems pretty narrow here leaving an awful lot of room for environmental influences, including epigentic ones on these particular pathways.
Beyond that, not sure what all you are seeing researchwise, but it seems to me like every piece of research I see in the genetics area is countered by three or four others now. And this is true even when a second team tries to replicate an earlier study. I expect this in things like efficacy studies of treatment regimens, but I’m perplexed about things that seem as controllable and “absolute” as molecular chem.
IDK.
I drink a lot of milk, so that should take care of my need for vitamin D. I also got some B-12 tablets. I think I’ll take one now.