Video: The mechanism of action of ulotaront (SEP-363856) in the brain

Medications
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Ulotaront, a trace amine-associated receptor 1 (TAAR1) and serotonin 5-HT1A receptors agonist, has demonstrated efficacy in the treatment of patients with an acute exacerbation of schizophrenia

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So it’s not a dopamine agonist at all? This stuff is so confusing to try to get a grip on. I get a handle on dopamine and serotonin receptors and then they throw this TAAR1 into the mix.
:laughing:
I wonder if it will work as well and not amplify negative symptoms as much.

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https://www.psychiatryadvisor.com/home/conference-highlights/psych-congress-2021/trace-amine-associated-receptor-1-agonist-ulotaront-for-negative-symptoms-in-schizophrenia/#:~:text=Ulotaront%20was%20found%20to%20be,%2C%20in%20San%20Antonio%2C%20Texas.

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Apparently it doesn’t bind to D2 receptors at all. I wonder if it will work as well for controlling positive symptoms though…

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It might still work just as well.

I really find it amusing that these kinds of videos are now a marketing strategy. I think it’s because of COVID and vaccine information videos.

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The more confusing part is that TAAR1 receptors indirectly affect dopamine function.

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From Wikipedia, “TAAR1 can reduce the firing rate of dopamine neurons, in turn preventing a hyper-dopaminergic state”.

I just hope its not another dopamine blocker, just with a fancy way of blocking dopamine.

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Well then it might just be a different route to the same result.

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Hopefully not, i think it lowers dopamine but not as much as by antagonizing dopamine receptora.

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