Again what are we hoping for …!!! Zeròooooooo…!!! I am crying man…!!!
For a better life which may not necessarily come from a cure. Recovery starts with acceptance.
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What is ur hope sticking to …no cas 9 no stem cell…
I am super dipressed today…
@far_cry0 you don’t understand, life in any form is precious…
I am eager to extend my life as much as possible and I don’t care about quality of life
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For me recovery is not possible …!!! I am bad off and on medication…i need a effective medication and cure…
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Yes it could be helpful.
Here’s an article on genetic editing some Japanese researchers did in a sz model of mice.
And another article:
And another
I won’t include all the links I have, but there is work being done now on viral vectors to introduce corrected genes to the adult brain. It’s mostly in Parkinson’s, Alzheimer’s, and a few rare genetic diseases, but in theory, it could work in any disease in which the continuing dysfunction of a gene drives symptoms.
Probably repairing what has gone wrong in the past would be difficult, but the brain has turned out to be more plastic than previously thought. There is also work being done on universal donor stem cells which would allow transplantation into anyone without rejection, and good consistency and quality control (screening for potentially harmful mutations).
There were several news articles awhile back on how valproate can turn back on a critical period in brain development that allows adults to develop “perfect pitch” a musical skill. How weird is that, and of marginal usefulness, but it does show that at least some critical periods can be restarted in adult humans with drugs (drugs can act on gene expression btw, or the products of gene expression, the protiens those genes express.)
Also at least in mice, critical periods of development can be restarted with stem cells.
http://www.sciencedirect.com/science/article/pii/S089662731500286X
Big pharma actually has gotten involved in investing in gene editing and stem cell technology. It’s a bit different model, but there’s no reason a cure could not be priced to be as profitable as pills, and still end up saving society money. Old technologies have always given way to new. I do think because this kind of research is high risk high reward, there should be more government funding and less reliance on private industry.
Unfortunately it’s all going to take awhile. I think when we see functional cures for Parkinson’s and Alzheimer’s that one for sz won’t be all that far behind, and that could happen this generation.
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When is their trail . Parkinson and alzhemers…???
There are clinical trials underway now, but it looks like they are not going to be full cures, not yet anyway. Just improvements in treatment. But it’s encouraging that they were able to progress to trials.
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I don’t think they will ever make a cure for us.
Based on what?
HIV has huge stigma, it’s very expensive to treat, drug companies could treat people for life, yet there’s major investment and major progress towards a cure.
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@Magicfish I love you!!
I must tell you though that I am more optimistic than you about a cure.
I have big plans for when my condition improves.
For you Erez I hope the cure is found
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@twinklestars I admire your focus on treatments and cures for schizophrenia and other diseases.
After all it is important not just to conduct research regarding treatments and cures,
it is also crucial to popularize this research.
And it is in this realm of popularizing research, where your main contribution is.
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HIV research is politicized to the max.
What we need is way more “positive awareness” about sz in order to boost research as they did with hiv. And we need way more money. Hiv research in the usa is about 35B USD/year.
That’s true. Activists got the funding for HIV where it is, it wouldn’t have happened otherwise.
Many diseases are caused by defects in how genes are built. The CRISPR technique allows a scientist to find that defect in the gene and correct it.
So, will CRISPR cure sz? Maybe. But it won’t be simple. Most diseases are caused by defects in multiple genes, not just one, as in sickle cell anemia. However, the technique already has been modified to edit multiple genes simultaneously.
More info - https://www.frontiersin.org/articles/10.3389/fnmol.2017.00204/full
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The only way to promote positive awareness fot Sz aimed at getting more research money is if we-those who suffer from it- give it a “Human” face, and not just the “Monster” face shown on the news stories. Nobody cares for monsters, they’d rather they just “Do away with them once and for all.”
We need to show the world we are doing the best we are able to everyday, and how much more we suffer because of the limits of the symptoms from SZ.
If all people see us as is a bunch of spoiled (because most don’t work), whiny crybabies who sit around all day complaining of everything, no one will show any compassion,which research money follows.
It’s up to each one of us to show them we are worth putting money into the research to help us become the best we can be- which in turns improves the quality of our community-which means everyone in the community.
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Updated topic. Added latest info about RNA editing.
It is my hope that CRISPR CAS9 or CAS13 should be fully mature for human editing in 10 years time.
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