Sodium Benzoate - normal food preservative for treatment of Negative symptoms of SZ

Medications
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Recent research shows that sodium benzoate may be beneficial as an add-on therapy (1 gram/day) in schizophrenia.[9][10][11] Total Positive and Negative Syndrome Scale scores dropped by 21% compared to placebo.
Wikipedia article on Sod. Ben. It is water soluble and 1CC (ml) volume is about 1.49g
As per Wikipedia ref 1g per day as ADD ON TREATMENT gives 21% better effect than placebo
ANY ONE HAD TRIED THIS ?

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Iā€™d like to see a study by a scientific organisation. What is referenced in the wikipedia?

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Hey bade bhai aap agaye phir ā€¦ur welcomeā€¦how are u and ur son.

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Thanks. He is OK. So how r u ? Doing well I suppose
Wish u the best

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Some people here have already tried sodium benzoate. Canā€™t remember names right now.

I am wary of studies who treat positive and negative symptoms at the same time. Would be interested to hear if sodium benzoate was effective against primary negative symptoms, especially anhedonia, in stable patients who were not experiencing positive symptoms at all.

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There are few studies on it. Wikipedia ref which I gave above has details. As per Wikipedia it is 21% more effective than placebo. The other ref also gives detailed evaluation by JAMA Psych edition.

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Good evening manoj bro ā€¦!!! Take careā€¦!!!

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Thanks looks like you r doing really good. Happy to know that.

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Am still strugglingā€¦does ur son have a job ā€¦can he workā€¦!!!

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No still long way to go.

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(see image below) The only item of the PANSS negative subscale that specifically measures motivation and pleasure is N4. Passive/apathetic social withdrawal ā€¦ Lots of the other items could be partly explained by positive symptoms or cognitive deficits. So, a 20% improvement in negative symptoms in the case of Sodium Benzoate doesnā€™t mean anything reallyā€¦ Like @Andrey said, they should specifically measure changes in anhedonia levels. All atypical antipsychotics supposedly improve negative symptoms but in the studies they never say which specific so-called negative symptoms actually improved: I suspect itā€™s because the PANSS negative subscale is just too broad and for example, antipsychotics may reduce paranoia which may have an impact on the Emotional withdrawal or Poor rapport items but none whatsoever on apathy/anhedonia/motivation. Atypical Antipsychotics also increase dopamine in the prefrontal cortex, the area of the brain responsible for cognition, and thus may improve the Abstract thinking item for example. For marketing purposes/ to sound good, companies will claim that antipsychotics improve negative symptoms ā€˜in generalā€™ā€¦

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Got published in JAMA.

https://www.ncbi.nlm.nih.gov/labs/articles/24089054/

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Liked the detailed analysis that you gave and many thanks for that. Would appreciate your comments on Sarcosine referred here in this forum

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Have u ordered sarcosine dear brotherā€¦!!

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Yes. Giving since last four days.

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Which brand do u orderd ebay or other brandā€¦have u notice any improvement ā€¦!!!

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I have tried sarcosine for about two weeks and felt nothing at all. Some people on this forum say it helped them from the very first dose with their lack of motivation, pleasure too I guessā€¦ Maybe I should have tried it for a longer period, but I doubt it would have changed anything. My problem seems to stem from an under-active mesolimbic dopaminergic system (main reward pathway in the brain), and only three substances, which all temporarily increase dopamine in that specific region, have helped me regain some motivation, and to some extent pleasure for a few hours, and those are Vyvanse (amphetamine), coffee, and ritalin. Sarcosine does not increase dopaminergic transmission, at least not in that part of the brain as far as I know. What are your symptoms @manojdivatia? Does music sound flat and everything seem colorless/grey and tasteless to you?

I may try agmatine next (which can be ordered online and which works in a similar way to one of ketamineā€™s mechanisms of action), maybe pramipexole alsoā€¦I may also ask for some kind of opiate like suboxone to take once a week (in order not to develop a tolerance) so I can have a break from this torture once in a whileā€¦I want opiates because the ā€œhighā€ is longer-lasting and smoother than that of amphetamines I thinkā€¦ Iā€™m also waiting for ALKS-5461 which is a new antidepressant coming out in 2018 which MAY work for anhedoniaā€¦

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Of which only coffee is available in my country :confused:

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