There is anyone on here that have been medicated with sep363856?


Is it some new med?

Yes. Is going through trial. Phase 3

Stronger than clozapine?

Different than any med that exists nowadays.

Googled article that says it’s being developed for the negative symptoms of Schizophrenia.

edit: this was for roluperidone before OP’s subject edit of sep-363856 not roluperidone

Why do you care about it?
You need it? The current APs don’t help?

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Sorry, I meant sep-363856. Not roluperidone.

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This medication works differently. It doesn’t influence the dopamine.

People are curious because it supposedly can also treat the negative and cognitive symptoms of schizophrenia (which are currently refractory to treatment). Moreover, no metabolic or sexual side effects. It is quite possible that future medications for SZ will be based on the mechanism of this medication and effectively the existing medications will become redundant.


Which one? The SEP…? It does influence dopamine but just indirectly via a different mechanism.

TAAR1 plays a significant role in regulating neurotransmission in dopamine, norepinephrine, and serotonin neurons in the CNS;

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My guess is that it will have less effects but wont completely treat negative symptoms as it still reduce dopamine but just indirectly via another mechanism than regular antipsychotics.

We will know the truth when it will be available.


Does Karxt indirectly affect dopamine? From my understanding it doesn’t but this stuff is hard to understand

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It’s doesn’t block the dopamine D2 receptors


Yea true but it affects TAAR1 which affects dopamine but we dont know yet how it affects dopamine, decrease or stabilize it etc We will know for sure when its released.

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