Schizophrenia risk and reproductive success: a Mendelian randomization study

These results suggest that increased genetic liability for schizophrenia does not confer a fitness advantage but does increase mating success.

What exactly does that mean? I am not sure how to interpret “genetic liability for schizophrenia”.

I guess it means that you’re vulnerable to having the disease but don’t actually have it (yet).

People seem to be attracted to my twin brother who isn’t Sz. He’s very emotionally dysregulated and a total loudmouth and show-off but people seem to find it amusing and attractive. To me it beggars belief that people would be attracted to someone like him, who’s emotionally a 2 year old.

I’m starting to think that basically everyone’s mad to some degree.

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Interesting, but number of children or number of sex partners are far from the only reproductive successes.

Example: perhaps the offspring of sz people are stronger in some way and thus used to have higher survival rates in natural circumstances. I read a research study that compared children of sz mothers and children of non-sz mothers. They controlled for other circumstances (poverty, abuse, etc). The children of sz mother did better in many fields.

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There has to be some reason why schizophrenia hasn’t been wiped out as a partially genetic disorder.

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Maybe there’s more druggies now so more people catching it aswell as more stress and plus its a genetic disease… So can be passed on

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I dont tend to see sz as an illness. I like the neurodiversity thinking.

Perhaps schizophrenia is a set of useful traits (e.g. thinking out of the box) with the dosing gone wrong.

Or a clash between the persons nature and the environment. A mismatch. Or a wound by a bad environment, bad for that specific person. E.g. if someone who is sensitive and creative lives in stressful circumstances like abuse or our current unnatural society…sensitivity and creativity might go awry. Whereas in a different environment they might flourish.

There is evidence of sz being connected to traits in offspring that are generally positively valued, as i said.

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Also our western societies have a very low tolerance to this type of differentness. If i hear voices people tell me i am ill, my brain is damaged, i have bad genetics, they lock me up and drug me and tell me i cant marry and work and have kids.

I can imagine in past societies mild sz actually might have increased my (reproductive) status, because they felt i could communicate with the spirit world or ancestors or so. And it would have been seen as a benefit to the group???

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I understand that they needed to give me medication but wish they didn’t shoot up the dose so high straight from the Start. I think they may have overmedicated me the first time round. Really wish I had had more of a say. They still do that in other countries I know in Africa they do @anon73478309 some parts. This guy I know of told me that they apparently learn how to control their voices… With their spiritual practices.

Yes i do wonder about that! I think “we” overestimate our western thinking and underestimate the thinking of people in other parts of the world. Not to say they are always right and know everything…or romantize it there…but our system has it flaws too, and theirs its value.

I’d love to know the statistics in these rural places. Compared to urban places like London. Of recovery or remission