Question about meds and brain damage

It seems lately that a bunch of people have been quitting and/or experimenting with antipsychotics. (you know who you are!). Whether it be on and off, or jumping from med to med without really giving it a shot.

I seem to recall from NAMI, or some other credible source but I can’t find the papers, that this type of behavior - the quitting or not be adherent to a regimen - will cause brain damage. More so than the meds themselves. Is this true? I could not find credible resources or research to confirm. Maybe @firemonkey knows of how to find this or if it is accurate.

And also after trying a drug out once then at a later time revisiting it, the odds that you will have success with that med is reduced. Then you are ■■■■ out of luck and have fewer options to try.

Any thoughts?..

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if you mean losing

either gray or white matter in the brain

yes that happens with this illness

I guess I don’t need all that though
I’m still pretty smart

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I read somewhere that almost all antipsychotics can cause brain shrinkage.
but apparently so does psychosis, so it’s a lose lose situation.

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How do they know it’s both were those studies done with a double blind.

Entrez pubmed 0 results
https://www.ncbi.nlm.nih.gov/pubmed/?term="antipsychotics"+"brain+damage"+"non+adherence"

Google scholar 147

https://scholar.google.co.uk/scholar?hl=en&as_sdt=0%2C5&q="antipsychotics"+"+brain+damage"+"non+adherence"&btnG=

It was difficult to find anything with a normal google search. What made a search difficult was the number of links of a “antipsychotics are evil” type .

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not a clue,
you’re probably right.

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There’s a lot of anecdotal evidence that people who stop treatment early on and relapse then go on not to do as well when they get back on meds. Did they not do as well because they stopped, or did they stop because they were sicker in the first place? Maybe a little of both?

There’s also evidence that earlier use of clozapine in TRS results in better outcomes, but later use of clozapine is not as effective, which suggests that the medication is providing some neuroprotective benefit.

There are also studies that switching from one 2nd gen AP to another isn’t substantially better or worse in terms of psychosis, but it does not address switching for reasons of side effects. Edit: some people have different levels of response to different drugs, but the studies are averaging everyone together. So I’m not saying that for you, risperidone is the same as olanzapine, only that statistically, for everyone, they’re pretty similar, psychosis wise.

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My pdoc says that sz/sza causes brain damage over time . The disease not the meds.

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@Skims, everything you said is true. It’s not the meds that cause brain damage but the psychosis that does.

And if you go off of meds that work, when you try them again, they might not work as good as before. That’s true.

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Antipsychotics with strong anticholinergic activity, like Haldol, cause brain shrinkage. Abilify and Paliperidone are two examples that don’t.

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So one I vega shot will have me back to normal in a year? It’s been four months since I got the 156mg

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Well rip my brain lol

In all seriousness though I’m doing fine and haven’t noticed any worsening in my condition despite all my shenanigans. Not that I’d recommend repeating my behavior.

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Pretty sure the haldol effed my brain then. I’m more messed up now then I was before I was on it

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Don’t count on the p doctor ever admitting that a ps cause this

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I took one forced Depot shot when does that ware off it’s been 4 months and still no dopamine

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Do you have any other CDs you can play?

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Sorry, but I find that hard to believe. Low dopamine maybe. One Invega shot will not do the amount of bad things you’re claiming it has . In fact your repeated posts about it suggest being on it ,or another depot, would be a good thing for you.

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Varies in person how the drugs effects your brain, its more of blocking receptors then damaging the brain. However if one has a adverse reaction or side effects then its a different thing all together.

Hope this helps.

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Its all b.s. i for one retire. I cant help.

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@firemonkey the first link you gave didn’t work.

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