People who stop weight loss drugs return to original weight within year, analysis finds

Medications
1
2 Likes
2

You need to be allowed to stay on a maintenance dose otherwise the appetite from hell returns. This is a fear I have.

1 Like
3

When i was in the hospital they didn’t give me my Mounjaro and i got an appetite from hell and gained 13 lbs in one month, so i definitely believe that article.

3 Likes
4

I’m on Mounjaro, didn’t come off of it but had my Depakote increased by one 500mg tablet and now I can’t stop eating!
I’ve gained over 20 pounds!
I’m going to beg my new doctor to have my dosage reduced back to 1000mg a day instead of the 1500mg dose

4 Likes
5

Appetite Dysregulation in Schizophrenia

Appetite disturbances in schizophrenia arise from both disease‐intrinsic and treatment‐related factors:

Intrinsic Factors:

    Interoceptive deficits may impair recognition of hunger/fullness, leading to irregular eating patterns.

Antipsychotic‐Induced Effects:

    Dopamine D₂ receptor antagonism increases ghrelin secretion and craving for calorie‐dense foods, promoting hyperphagia and weight gain

Interoceptive deficits also occur in autism.

2 Likes
6

I’ve always been a hungry boi my entire life, but after Zyprexa I lost the ability to be full and NOT be hungry. I can eat until I want to puke and still want to eat now (without the weight loss jab). That was another bit of damage done to me by the Devil Med.

3 Likes
7

Going off topic slightly.

Cardiac interoception—the ability to sense and interpret one’s own heartbeat—provides a window into how bodily signals inform emotional and self‑related processes. In schizophrenia, a growing body of work reveals systematic disturbances in cardiac interoceptive processing, which may underlie key clinical features such as self‑disturbances and emotion dysregulation.

1. Behavioral Evidence of Impaired Heartbeat Perception

  • Heart Rate Discrimination Deficits: In a recent psychophysical study (n = 43 with psychosis vs. 41 controls), patients with schizophrenia or schizoaffective disorder showed significantly larger thresholds for discriminating auditory tones as faster/slower than their actual heart rate—indicating misestimation of cardiac signals specific to interoception (no group differences in an exteroceptive control) (PubMed).
  • Reduced Interoceptive Accuracy (IAcc): Multiple heartbeat counting and discrimination studies consistently find that individuals with schizophrenia score lower on IAcc measures compared to healthy controls (e.g., p = .017) (Oxford Academic, PMC).

2. Neural Correlates: From Cortex to Brainstem

  • Insular Cortex Hypoactivity: The right anterior insula—critical for mapping visceral signals—shows reduced activation and altered functional connectivity in schizophrenia during cardiac attention tasks, correlating with poorer heartbeat detection.
  • Heartbeat‑Evoked Potentials (HEPs): EEG studies reveal attenuated HEP amplitudes in patients, suggesting blunted cortical registration of each heartbeat cycle (ScienceDirect).
  • Anterior Cingulate & Somatosensory Relays: Disruption in cingulo‐insular circuits and compromised transmission of baroreceptor afferents may further degrade cardiac signal integration.

3. Clinical Significance: Symptoms and Self‑Disturbance

  • Positive and Self‑Disturbance Correlations: Lower IAcc has been linked to more severe positive symptoms—especially grandiosity—and to core self‑disturbances (e.g., fragmented body ownership, sense of agency) (Frontiers, Frontiers).
  • Sense of Agency (SoA): A recent study showed that whereas cardiac systole typically enhances implicit SoA in healthy individuals, it disrupts SoA in schizophrenia, with the magnitude of this disruption correlating with hospital admissions for hallucinations/delusions (Frontiers).

4. Mechanistic Implications and Treatment Directions

  1. Biofeedback & Interoceptive Training: Targeted heartbeat biofeedback (e.g., auditory or vibrotactile feedback tied to one’s ECG) can increase IAcc in healthy and clinical populations alike—offering a potential adjunctive therapy to restore bodily self‑monitoring.
  2. Mindfulness‑Based Interventions: Practices that cultivate non‑judgmental attention to bodily sensations may rebalance aberrant insula–ACC activity and improve emotion regulation.
  3. Transdiagnostic Targets: Because interoceptive deficits span anxiety, depression, eating disorders, and psychosis, integrating interoception modules into psychiatric rehabilitation could yield broad benefits.

In summary, cardiac interoceptive processing is robustly impaired in schizophrenia—manifesting as misestimation of heartbeat, blunted cortical potentials, and altered self‑agency—linking visceral awareness to core symptoms. Future work should test whether restoring cardiac interoception ameliorates both self‑disturbance and clinical outcomes.

I was asked several in school to measure my heartbeat. I’ve never been able to do it.

1 Like
8

I booked an appointment to ask if possible to be considered for the weight loss jabs, but now I don’t think there’s a point.

2 Likes
9

I used to wear XXXL jackets.

image
image800×1067 58.2 KB

This is the LG jacket I purchased for myself this week. It fits. There’s a point.

Go for it.

1 Like
10

I’m on olanzapine (zyprexa). I had insatiable hunger until I started eating high protein, low carb (not no carb) breakfasts and for lunch and dinner having 1/2 to 1 cup of rice with lean protein and veggies. I never have more than a total of 1.5 cups of cooked rice per day.

I don’t know why, but it’s working so far.

2 Likes