I’m gaining all my weight back.
Since having my Depakote dose increased to 1500mg I’ve gained over 12 pounds within a months time.
The Mounjaro injections are no longer working for weight loss.
My psychiatrist is counting on the Mounjaro to help neutralize the Depakote weight gaining effects but like I said it’s not working.
It’s so difficult controlling my appetite
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Exercise man. Exercise. Even if you dont lose weight, you feel better. Since hanging out with fiance/girlfriend more I have so much more energy.
I know this is due to all the trips to walk around the store, other places and walking up and down her 2 flights of stairs to her condo…this and all the running around looking for the right house, etc.
I cant guarantee weight loss, although some probably would come with it, but you feel so much better and have so much more energy.
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Carrying 6 bags of groceries up flights of stairs is good exercise.
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I’m on the move now all day long
Walking my dog sometimes five times a day.
Im still fat
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Maybe you need to cut calories as well? I dont know @Wave . All I know is that I feel so much better now and my diabetes is very well controlled. I have not lost huge amounts of weight either, but every little bit helps.
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Yeah unfortunately Depakotes unfortunate nickname is Depabloat
It’s a notoriously huge weight gaining med.
It slows down your metabolism almost as much as Zyprexa, it also makes you constantly hungry even after eating a large meal.
But yes @Bowens I’m not going to give up.
Thanks for your support
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Don’t feel too bad @Wave…i gained 12-13 lbs during the month i was in the hospital and feel big and fat because of it, but i know that if i get my eating and exercise back on track, i can eventually lose it again. Even tho my physical doc was happy with the weight i gained, i was NOT and want to get back to 144 lbs again. I don’t care if i “needed” to gain some weight (according to the doc). I feel bloated and fat.
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Thanks @WhiteRaven
@Wave, my metabolism never sped up again after getting whacked by Zyprexa. Saxenda and Wegovy are actually weight neutral for me without exercise. I also do some calorie reduction, but it’s easier when you’re not constantly starving.
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There is preliminary evidence that persons with schizophrenia
experience satiety differently and may have abnormal gastric electrical
activities. One study found that individuals with schizophrenia report
lower levels of satiety than healthy controls following a similar amount
of food consumption (Waltz et al., 2015); however, it is unclear whether
this effect was due to higher rates of obesity in persons with schizophrenia, as obesity is associated with delayed satiation and accelerated
gastric emptying of solids and liquids (Acosta et al., 2015). In addition,
unmedicated persons with schizophrenia exhibited increased tachygastria, an increased rate of electrical pacemaker activity in the stomach that is indicative of sympathetic activity (Peupelmann et al., 2009b).
Moreover, such increased sympathetic modulation in the enteric nervous system was more prominent in those with more severe delusions.
Schizophrenia is furthermore associated with significant weight gain
that is partly (Manu et al., 2015), but not entirely, due to antipsychotic
use. To maintain a healthy weight and optimal energy regulation, blood
glucose level is maintained within a narrow range by hormones like
insulin and glucagon (Aronoff et al., 2004). Glucose regulation is
impaired even in first-episode, drug-naïve individuals with schizophrenia with normal BMI and no comorbid medical conditions (Spelman
et al., 2007). Moreover, impaired glucose regulation is similarly
elevated in unaffected first-degree relatives of individuals with schizophrenia, suggesting a shared genetic or environmental factor that is not
related to antipsychotic exposure. Interestingly, in a population-based
genome-wide association study, a well-known diabetes risk gene
variant is found to be associated with schizophrenia (Hansen et al.,
2011), potentially indicating common mechanisms underlying the psychiatric and metabolic conditions, such as inflammation (Perry et al.,
2020).
https://cnl.psy.msu.edu/wp-content/uploads/2021/11/1-s2.0-S0149763421005091-main.pdf
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