Chime in with opinions!
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Twenty-six weeks of extension phase treatment was associated with a mean (95% CI) observed change from open-label baseline in the PANSS total score of -22.6 (-25.6, -19.6; effect size, 1.46), and a mean (95% CI) change in the CGI-Severity score of -1.0 (-1.2, -0.8; effect size, 1.07). Long-term treatment with the TAAR1 agonist ulotaront, in the daily dose range of 25-75 mg, was characterized by a relatively high completion rate, an adverse event profile notable for the absence of extrapyramidal-related adverse effects, a low liability for adverse weight and metabolic effects, and no effect on prolactin levels.
Sounds promising. On the other side, in a long term study a significant number dropped out, even though the patients might have been pre screened for stability. I do not want to over hype the med for that reason.
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Can someone let me know what a 95% CI change means?
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Confidence Interval article:
https://en.m.wikipedia.org/wiki/Confidence_interval
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The study completion rate after 26 weeks of open-label treatment with ulotaront (67%) was relatively high compared to 26-week completion rates of 39–65% reported previously in other long-term studies of atypical antipsychotics12–14. Estimated discontinuation rates at 6 months (based on KM plots) from the Clinical Antipsychotic Trials of Intervention Effectiveness (CATIE) study13 provide a useful benchmark for comparison with the current results given the “real world” features of the study. Olanzapine had the highest 6-month completion rate (55%), while rates were notably lower for risperidone (43%), perphenazine (41%), quetiapine (39%), and ziprasidone (38%).
its not bad
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That’s a quite good antipsychotic if you’ve gotten side effects
From the current therapies but offers little hope for
Us who mainly suffer from negative or cognitive symptoms
I give up because to me it seems they have given up
On finding a treatment that offers hope for those of us who
Suffer from deficit symptoms.
Guess that I’ve to stay on Clopixol and Seroquel because
I really don’t suffer that much from side effect so it
Would be like throwing money out of the window to
Buy this rather useless drug.
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An antipsychotic is also coming out that works by treating the negative symptoms. It’s called KarxT.
Never lose hope.
I really just want a drug that stops the weight gain and sexual disfunction