NAC for psychosis and depression

jeroenp · November 30, 2016, 10:04pm

ncbi.nlm.nih.gov

Beneficial effects of N-acetylcysteine in treatment resistant schizophrenia.

M Bulut, HA Savas, A Altindag, O Virit and A Dalkilic, The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry, 2009

Poor response to antipsychotics is still an important problem in the treatment of many schizophrenia patients. N-acetylcysteine (NAC) is a compound that exerts anti-oxidant and scavenging actions against reactive oxygen species. This paper reports a case of poorly responsive schizophrenia patient who improved considerably with add-on NAC 600 mg/day. The NAC might work through activating cysteine-glutamate antiporters or reducing in nitric oxide (NO) metabolites, free radicals and cytokines or through both of these mechanisms.

jeroenp · November 30, 2016, 10:46pm

I think NAC from vital nutrients is good, i read positive comments about it

anon11056724 · December 4, 2016, 4:06am

been taking this stuff for 6 months. Haven’t noticed anything different

Green · December 4, 2016, 11:58am

I went through 2 bottles and sadly just felt the same, so I might pass on it from now on.

far_cry0 · December 4, 2016, 12:10pm

@jeroenp have u tried Sarcosine L-theanine and vitamin pregnenolone…???

jeroenp · December 5, 2016, 10:49pm

nope thanks for mentioning it, i tried Sarcosine tho

jeroenp · December 7, 2016, 9:13pm

haven’t tried L-theanine and vitamin pregnenolone

does L-theanine works on the negatives?

far_cry0 · December 8, 2016, 4:18am

It is said that vitamin pregnenolone and L-theanine works for negative symptoms…!!!

anon11056724 · December 8, 2016, 4:49am

■■■■ don’t work

jeroenp · December 8, 2016, 1:11pm

Does pregnenolone has cardiac issues, i’ve read someone on the board has chest pains correct me if i’m wrong

what about L-theanine ?

far_cry0 · December 8, 2016, 1:16pm

I don’t know much about cardiac issues…!!

see…!!!

ncbi.nlm.nih.gov

Add-on Pregnenolone with L-Theanine to Antipsychotic Therapy Relieves Negative and Anxiety Symptoms of Schizophrenia: An 8-week, randomized, double-blind, placebo-controlled trial.

A Kardashev, Y Ratner and MS Ritsner, Clinical schizophrenia & related psychoses, Jul 28 2015

Pregnenolone (PREG) and L-Theanine (LT) have shown ameliorative effects on various schizophrenia symptoms. This is the first study to evaluate the efficacy and safety of augmentation of antipsychotic treatment among patients with chronic schizophrenia or schizoaffective disorder with PREG - LT.Double-blind, placebo-controlled trial of PREG - LT or placebo augmentation was conducted for 8 weeks with 40 chronic DSM-IV schizophrenia and schizoaffective disorder patients with suboptimal response to antipsychotics. Oral PREG (50 mg/day) with LT (400 mg/day) or placebo were added to a stable regimen of antipsychotic medication from March 2011 to October 2013. The participants were rated using the Scale for the Assessment of Negative Symptoms (SANS), Hamilton Scale for Anxiety (HAM-A), and Positive and Negative Syndrome Scale (PANSS) scales bi-weekly. The decrease of SANS and HAM-A scores were the co-primary outcomes. Secondary outcomes included assessments of general functioning and side effects.Negative symptoms such as blunted affect, alogia, and anhedonia (SANS) were found to be significantly improved, with moderate effect sizes among patients who received PREG-LT, in comparison with the placebo group. Add-on PREG-LT also significantly associated with a reduction of anxiety scores such as anxious mood, tension, and cardiovascular symptoms (HAM-A), and elevation of general functioning (GAF). Positive symptoms, antipsychotic agents, concomitant drugs, and illness duration did not associate significantly with effect of PREG-LT augmentation. PREG-LT was well-tolerated.Pregnenolone with L-Theanine augmentation may offer a new therapeutic strategy for treatment of negative and anxiety symptoms in schizophrenia and schizoaffective disorder. Further studies are warranted.clinicaltrials.gov Identifier: NCT01831986.

jeroenp · December 8, 2016, 2:55pm

both combined ? or am i reading this wrong : s

thanks

far_cry0 · December 8, 2016, 2:57pm

yes
both combined…
l theanine alone for positive symptoms and pregnenolone for negative symptoms…!!!

jeroenp · December 8, 2016, 2:59pm

cool sounds good

what should be the starting dose for pregnenolone

far_cry0 · December 8, 2016, 3:03pm

may be 50 mg…!!!

Vitamin Pregnenolone - New Treatment for Schizophrenia - anyone trying it? DX'd - Other

Please let me know if you have tried pregnenolone? What effects positive or negative have you noticed? If you haven’t tried it - perhaps try it and report back. I’ve read that it can be helpful in negative symptoms that are common in schizophrenia. The dosing in the top study was 50 mg per day. It can be purchased here (this link is a google shopping search: https://www.google.com/?gws_rd=ssl#q=Pregnenolone&safe=off&tbm=shop I found some clinical trials that had demonstrated effect… Pregnenolone treatment reduces severity of negative symptoms in recent-onset schizophrenia: an 8-week, double-blind, randomized add-on two-center trial. Ritsner MS1, Bawakny H, Kreinin A. Neuroscienc…

jeroenp · December 8, 2016, 3:05pm

Ok, @far_cry0 thanks

jeroenp · December 8, 2016, 3:06pm

My negative symptoms are also bad, but they give me shame and many problems in daily functioning :s

jeroenp · December 8, 2016, 3:07pm

especially those paranoid delusions, i am trying to ignore them but sometimes they take the upper hand ; (

far_cry0 · December 8, 2016, 3:09pm

My both negative and cognitive symptoms are bad…!!!

far_cry0 · December 8, 2016, 3:09pm

i am trying them out soon…!!!