A lot of people here are already on metformin
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Awesome
I am on Metformin, yeah I heard about its anti aging effects - its really a good drug for Diabetes.
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Did you notice any ‘youthful’ effects after taking it?
She did it without metformin!
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And the social security systems around the world groan in agony! 
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lol No not really, but my blood glucose levels are under control.
Metformin is one of the safer diabetes drugs out there.
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I’m surprised there hasn’t been more replies to this. It’s an interesting article.
**Good genes…
**
This is very interesting. I’m going to try not to get my hopes up too high, though.
There was a time when many scientists seemed to suspect that a program of pretty extreme caloric restriction might help people to live to 120 to 130 because it seemed to help animals to do so. Then recently some scientists showed that caloric restriction did not seem to extend the lifespan of rhesus monkeys.
My point to bringing that up is that lifespan extension in humans and other similar primates may work differently than some of the animals that they tested the metformin on so far. Humans have a longer lifespan than some animals already, possibly because we have a lower metabolism and burn less calories in some ways.
Metformin is a diabetes drug, and that would seem to be related to metabolism also.
I hope to watch this though. Maybe metformin slows some type of metabolism down even further in some way: some kind of metabolism that is particularly related to aging.
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“When Belgian researchers tested metformin on the tiny roundworm C.elegans the worms not only aged slower, but they also stayed healthier longer. They did not slow down or develop wrinkles. Mice treated with metformin increased their lifespan by nearly 40 per cent and their bones were also stronger.”
This got me thinking, so I found something that I think is interesting:
"A pharmacological network for lifespan extension in Caenorhabditis elegans"
If you look at the left column in table 1, it lists a substance “Loxapine succinate.” Then it shows that it targets “DRD2 (DRD1, D3, D4, D5…” (dopamine receptors, I believe.) Then, the second to last column indicates a 43% increase in the lifespan of C.elegans. Guess what “Loxapine succinate” is? It appears to be an antipsychotic!
Maybe it hasn’t gotten the media attention because people wouldn’t take antipsychotics to live longer quite as readily…
http://www.hopkinsmedicine.org/news/media/releases/study_use_of_antipsychotic_drugs_improves_life_expectancy_for_individuals_with_schizophrenia
Of course, that begs the question: If some antipsychotics can extend the lifespan of c.elegans so dramatically, why do so many people with schizophrenia die so relatively young? I don’t know; but, common sense might point toward the smoking and the caffeine use and stuff…
"Use of caffeine and nicotine in people with schizophrenia."
Also, since withdrawing from a medication seems to often cause the opposite effect that the medication caused, I wonder if withdrawal from Loxapine might shorten lifespan. There’s a thought for the next time I want to withdraw from my 1 mg of Haldol daily…
Hrrrmmm… speculation…
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I would have mixed feelings about living that long. If I had engaging work to do I might like it. If I needed more time to accomplish what I wanted to accomplish.
I don’t want to live till I’m 120 honestly, just drooling on myself watching game shows. No thank you ill pass
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