Time for me to quit nicotine. I don’t know how long I’m going to last, but I hope I can finally quit after being 2 years smoke free (figuratively speaking).
I find that L-Theanine + Caffeine is a better option for cognitive enhancement.
I also found this:
X Di, J Yan, Y Zhao, Y Chang and B Zhao,
Science China. Life sciences , Dec 2012
In this study, the inhibitory effect of L-theanine, an amino acid derivative of tea, on the rewarding effects of nicotine and its underlying mechanisms of action were studied. We found that L-theanine inhibited the rewarding effects of nicotine in a conditioned place preference (CPP) model of the mouse and reduced the excitatory status induced by nicotine in SH-SY5Y cells to the same extent as the nicotine receptor inhibitor dihydro-beta-erythroidine (DHβE). Further studies using high performance liquid chromatography, western blotting and immunofluorescence staining analyses showed that L-theanine significantly inhibited nicotine-induced tyrosine hydroxylase (TH) expression and dopamine production in the midbrain of mice. L-theanine treatment also reduced the upregulation of the α(4), β(2) and α(7) nicotine acetylcholine receptor (nAChR) subunits induced by nicotine in mouse brain regions that related to the dopamine reward pathway, thus decreasing the number of cells that could react to nicotine. In addition, L-theanine treatment inhibited nicotine-induced c-Fos expression in the reward circuit related areas of the mouse brain. Knockdown of c-Fos by siRNA inhibited the excitatory status of cells but not the upregulation of TH induced by nicotine in SH-SY5Y cells. Overall, the present study showed that L-theanine reduced the nicotine-induced reward effects via inhibition of the nAChR-dopamine reward pathway. These results may offer new therapeutic strategies for treatment of tobacco addiction.
Which would explain why nicotine had a little effect on me when I was using L Theanine.
I hope I can pull through the day.
9 Likes
Good luck! My brother went cold turkey a year ago and he’s been smoking for over twenty years. If he can do it, I believe almost anyone can… Maybe I’m underestimating him though.
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LED
February 14, 2018, 9:03pm
4
Just a setback, not a failure. Keep trying!
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I thought L Theanine would work better but I was wrong. I’ll just stick to my nicotine lozenges.
system
May 15, 2018, 9:46pm
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