hello friends,
Does any body know why ITI007 would have low EPS (Tardive diskinesia,dystonia etc)? What is the reason given by company that makes it safer against TD and other side effects compared to current lot (abilify etc ) in market.
Thanking in Advance,
āIn the long run, she said, it will be important to know whether the drug ā like all other antipsychotics ā will eventually cause tardive dyskinesia. But that adverse event usually takes months or years to develop and is unlikely to be seen in short clinical trials, she saidā.
Not sure how long clinical trials were? can not be just 28 days??? it takes average 5-6 years for clinical trials isnāt it?
The new antipsychotics being developed modulate dopamine activity in the brain, instead of just blocking it, they should have a lower incidence of causing TD.
According to wikipedia:
āUnlike most current antipsychotics, such as haloperidol, risperidone, and olanzapine, lumateperone does not disrupt striatal dopamine signaling, a property which is likely due to its partial agonism of presynaptic D2 receptors.[6] In accordance, similarly to aripiprazole, which is also a partial agonist of presynaptic D2 receptors, lumateperone showed no striatum-based motor side effects (i.e., catalepsy) in animals.[6]ā
The phase 3 clinical trials were 6 weeks. It takes 3 or more years though because of all the preparation, recruitment, analysis etc. They donāt start everyone at the same time, generally.
I think there is an ongoing open label study that is longer, but I canāt find it.
@twinklestars, do you know:
is high affinity ratio good thing or bad thing? Seems like ITI 007 (59) has no parallel in that. Clozapine (20) is distant second while abilify etc are no where in the game. Any idea?
Appreciate your input,
I donāt know that it is necessarily good or bad it just describes its binding to 5-HT2A vs D2. Itās novel, in any case.
"Lumateperone shows a 60-fold difference in its affinities for the 5-HT2A and D2 receptors, which is far greater than that of most or all existing atypical antipsychotics, such as risperidone (12-fold), olanzapine (12.4-fold), and aripiprazole (0.18-fold).[6][9]
It is thought that this property may improve the effectiveness and reduce the side effect profile of lumateperone relative to currently-available antipsychotics, a hypothesis which is supported by the observation of minimal catalepsy in mice treated with the drug.
Moreover, it has been expressed that this property could result in full occupancy and blockade of the 5-HT2A at low doses, with dose-dependent adjustable modulation of the D2 receptor, as well as the SERT, possible with increasing doses, which would uniquely allow for clinical optimization of efficacy and side effect incidence
So itās good if you want a full blockade of the 5-HT2A before D2.
Exactly how that will work for the individual is probably, well, individual.
Iām currently on the study and have been doing well, started at the end of October. Good energy and doing well with symptoms. Breakthrough symptoms when under too much stress, but overall I deal with stress better than on most other meds work Iāve used over the years.
I usually respond pretty well to meds now that Iām not doing any more street drugs and only drink once in a while.
Everyone responds to meds differently, so if itās approved, it still might not be the best for you.
But at one point I saw something somewhere on the internet that this particular med would be the first in the next generation of meds., because of some of the differences in the way it works, as opposed to older meds.
Honestly it is weird but sine adding vit e and b6 it seems to help with the combo of artane generic. I donāt pucker my lips at all now. With artane I used to when would start to wear off.
I could be wrong, but I believed it said that it can help with negative symptoms too. I think thatās why itās significant enough to be considered different from those that came before.
My qt was over 570 at on point and have vtach cuz of meds. I have long qts, I canāt take jack ā ā ā ā unless approved by four different drsš°
if you have bad TD you should really ask them about Ingrezza. anti parkinsons drug develop resistance after sometime.
Talked to dr nope prolongues your qt. It could KILL me
āAnd another one bites the dustā Plus looked up on my qt site Iām registered on. Ty though
Ty but I already told you Iām only allowed on jack ā ā ā ā . Itās very depressing when you canāt even take theraflu for instance and die
Sorry to hear that. Hope they find medicine without side effects soon.
do not forget if your TD gets worse you can try Deep Brain Stimulation. They are working on non invasive DBS now so that surgery will not be necessary.
Hope so too. Sorry if was irritated my cardio nurse was irritated I didnāt look at my qt app first. Dumb on my part.
Can prolonged QT go away?
Inherited long QT syndrome does not go away. If you have a long QT interval caused by a medication you are taking or by a mineral imbalance, it will most likely go away once you stop taking the medication or treat the imbalance.