What are its side effects…!!!
But min 101 is too far way. If i could try cariprazine first just to see if it works It would be much better cause if i don’t i will be on the doubt if it works or not. But I have 3 problems: first I have to wait for it to arrive to europe, second i don’t know if my pdoc is going to prescribe vraylar to me; and third it’s very expensive, although the meds here are much more cheap (portugal) i think i will strougle to aford it…
1 Like
I’m waiting for Rexulti and Vraylar to arrive to Portugal as well… We’ll see. I’m not too eager though, letting things take their time.
Side effects of vraylar?
1 Like
Our friend @HuckFinn is on Vraylar …he can better tell us about med experience…!!!
I am not so positive about Vralyar >>>lets wait for min 101…!!!
Hi @Minnii you once told me it could take 3 years too arrive here, I didn’t want to believe that because i was too eager for the med to get here. But i guess you were right tough. Sorry about that. 
2 Likes
That’s alright. I just posted a study about the impact of CETA, between Canada and the EU. That agreement should accelerate the arrival of new meds to the EU, by increasing the costs of meds in Canada. It’s a win-lose situation.
It’s good for us anyways but I feel bad for the canadians. @austinsdad and @HuckFinn are on vraylar and they are much better I think
It’s not a big rise, and I was just reading that the governement is covering the expenses, so I guess it’s alright
From what I’ve seen on the internet phase III lasts from 1 to 4 years. I don’t know if the FDA has given min-101 fast track designation, if it did it would probably take less time.
1 Like
Actually, phase 3 can be divided into several parts, usually labeled phase 3-a, 3-b etc. Each of these parts takes 6 months at most, from what I gather. But you’re right, globally it could extend up to a couple years.
1 Like
in the article posted in the subject of the thread “absence of drugs targeting negative sx…”
2 Likes
Once they find the med to treat negative symptoms i think it will be going to flood of medicine… Am i right here…??
Well they’ve been lazy so far, or maybe they just don’t understand how to treat negative sx. Maybe negative sx are caused by something irreversible and it is impossible to treat them with drugs which effect neurotransmitters.
I think you are right, sz is a very dependable market of 1% of everyone in the world. Once a drug treating negative sx comes out most sz patients will want to be on it. They are calling negative sx a major unmet therapeutic need for a reason. In the end it really depends on the effectiveness of the med, does it do what it is supposed to? We are trying to figure that out, that’s what the clinical trials are for. Personally I am not putting my money on this one, it is a mechanism which has been used for many years (5ht2a antagonism) and hasn’t treated negative sx so far, if atypical antipsychotics which block 5ht2a haven’t cured your negative sx I don’t see how this magically will.
1 Like
May be this is not true… its really too early to bet on it…If min101 passes all its hurdle negative symptoms are all treatable…let’s wait and watch…!!!
1 Like
They basically just made an atypical antipsychotic without any D2 antagonism, I’m not a chemist but to me it seems like drugs which work by this mechanism already exist.
…already exist and do nothing for negative symptoms.
1 Like
I back ur thought that negative symptoms are cause by something irrecoverable neurotransmitter …i googled a lot…!!
there is no single article that support my ideas…i am not 100% pessimistic that it do nothing for negative symptoms…we have only one choice left wait and watch…!!!
Many people say negative symptoms are cause by loss of gray matter in brain…it’s impossible to regrow gray matter by drugs or any other form…let’s keep our hope alive…!!!
1 Like
I think there might be a many different causes for negative sx. If it doesn’t have to do with neurotransmitters and its actual structural/connectivity type dysfunctionthen what can standard neurotransmitter drugs do for us?
If its grey matter maybe the focus will have to be on preventing loss over time. I agree, we need to keep hope alive but you get to a point when you can only get disappointed so much then you get pessimistic.
1 Like
hey @eduvigis are u from Kampala…???
1 Like
A lot of my family is from there but I live in Minnesota.
1 Like