Is it normal for symptoms to get worse while waiting for your anti-psychotic to kick in (injection)?

I made a quick switch from Invega Injection/Invega tablets to the Abilify injection/invega tablets. its been about two months and I’m on 400mg of ablilify and my symptoms were really bad this month.

I’m switching to every 3 weeks this week but I’m worried it still wont work.

Are you saying you’ve been on the injection for 2 months? You should definitely be noticing something beneficial by now.

I think it is quite normal. Would give it another 6 weeks to get the full benefit.

I don’t feel any benefits. I felt like Invega was working better but I had to make the switch because of the Akathisia. You mentioned you were on abilify oral right? When did that start to work for you?

Actually, when I first took it during my first hospitalisation it took about 3 months. So… dunno. It shouldn’t take that long if you’re switching to it though.

Having said that, There is some evidence that abilify can make you worse for a while when switching as it behaves differently with regards to dopamine.

If you are switching to Abilify from another AP that is not a partial agonist, yes I’ve heard it can aggravate your symptoms. This is because your body is used to having a full antagonist of dopamine in its system-fully closing your dopamine channels. Abilify in a person who has not been on an antagonist closes channels but not fully, leaving them partially open so they get less dopamine than before. But in your case it is slightly opening channels that were fully closed on your old meds, leading to a temporary increase in dopamine, leading to spiked symptoms.

Hopefully that will go away once your brain adjusts. Abilify wasn’t strong enough to take away all my symptoms and only helped calm my paranoia.

2 Likes

A terrible transition of medication I did this with risperidone and it made me so ill.

Drop abilify keep invega shot. Consider Risperidone consta if unhappy with invega shot