Inconstant sedation from seroquel

Most nights after I take my seroquel I feel pretty sedated.

But on some days I don’t feel any different even after a couple of hours, and I naturally drift to sleep like I used to before medication.

I considered it could be due to: being on an empty stomach, being on a full stomach, feeling good that specific day, feeling bad during that day and a few other things. But none seem to be it.

Has something like this happened to anybody else?

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do you have a sleeping disorder?

What dose of seroquel do you take?

Do you take it at the same time every day?

Are you take the immediate release form or the XR extended release form?

Not that I’m aware of

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I take 300mg XR every day around the same time, from 6:30 to 7:30 PM.

It might be due to the fact it’s XR. Who knows how consistent that release is.

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Welcome to the forum! @OrdinaryWeather

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First, welcome to the forum.
I am on 300mg of Seroquel. I take it at nite. It knocked me out like an off switch for a while. If I missed a dose I just don’t sleep at all till I get a dose. That was until recently. Now I’m taking longer to sleep and sleeping for half as long as when I started taking it. I’m going to speak to my Pdoc soon. I don’t know if it’s a tolerance issue or my brain cooking up some fun. To me it sounds like you should talk to your doc to workout what is causing the inconsistency and determine if it’s a problem. As for my issue, I feel like mania and quetiapine are fighting it out. So I’m going to talk to my Pdoc.

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I think it’s worth talking to your doc about these too

I was talking to a few GPs on Friday about on sleep medication that wasn’t working well, before getting a very low dose of Seroquel which helped. But one thing they mentioned, that I hadn’t considered, was managing my body clock in general. (I’d slipped on it because of a bad week)

So outside of medication, helping to set the body clock includes things like:

  • standing outside in sunshine / daylight earlier in the day (outside light is much brighter than inside light, and helps your body to know when it’s day and night)
  • consistent meal times
  • getting to exercise consistently, and not too late in the day

But as I mentioned, it would be worth talking to your doc again

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Welcome @OrdinaryWeather.

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Enjoy your stay with us!

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