If you have a treatment resistant depression and tried every AD on the market, then you should consider an MAO - inhibitor (one of the oldest and strongest AD’s)
I have tried several AD’s without getting better, but now i’m taking Isocarboxide and it’s beginning to work. It’s not perfect, but the overwhelming sadness and suicide ideation are gone.
Warning: If you have problems with positive symptoms or manic episodes Isocarboxide and other MAO-inhibitors might worsen them because MAO-I increase levels of dopamine in the brain.
Second warning: You have to avoid certain foods that elevate tyramine in the blood, fermented food, soya sauce, old cheese and stuff like that.
Third warning: There are several kind of medications you cant take with an MAO -i because you risk a serotonergic overdose.