I dont belive in stem cell and crisper..i trust in finding out the biological causes of sz

@GentleSoul let’s not predict the future.
Anything is possible.
For people whose condition is good, they can take responsibility and avoid loneliness.
For me it is not practical.

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Dont be sad gentle soul …ur still young…!!! U are lovable in this forum and this world…

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I think you’re misunderstanding me. We know many causes, plural, of sz. Even in individual cases where we can already say “this person has the 22.q.11.2 genetic deletion” we can’t cure them. Keep following me here, I’m getting to a point. If we’re going to fix a genetic defect, that’s going to require, in part, a genetic editor, such as CRISPR. That is why I say what I said, since farcry says he doesn’t think anything will happen in stem cells or CRISPR.

By the way, all of the environmental risks still go back to epigenetics. Illness, stress, drug and chemical exposure, deficiency, even head injuries, all of that, they make epigenetic changes. So we don’t necessarily have to know what happened to cause the epigenetic change, just how to switch it back. And then of course to restart normal brain development, which is really the hard part.

But as I have said before, we already know that valproate restarts the critical period for learning perfect pitch, other critical periods might also be reopened. In mice, we know the introduction of stem cells to the visual cortex restarts visual development. So these things aren’t physically impossible.

So, unlike farcry, I still have hope for stem cells and CRISPR, but I was asking him why he lost his hope in those technologies being feasable in less than 100 years.

I don’t think it’s possible to make accurate predictions past 25 years or so in the medical field, because we’ll have new tools we can’t even imagine now.

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Well I have an answer for you.
You ask why farcry doesn’t think anything will happen in stem cells or CRISPR.
That’s because having low expectations is a coping mechanism.
Having low expectations helps him cope with his condition.
@twinklestars

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I understand that. But it’s different from his usual hopeful attitude so I was wondering what happened.

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There was a paper on muscimol and schizophrenia from 1978. I haven’t read it. You can search both terms together though and there’s a sprinkling of papers.

I am still young but soon enough I’ll be old and lonely and sick as all ■■■■.

You realize that stuff is what would “fix” the genetic issues of sz right? :joy: Like just finding out oh it’s these specific genes that cause it would not cure us. Crispr is what can alter certain gene sequences so it would act to repair. (That’s my basic understanding of it)

That’s like saying, “I don’t care about antibiotics, I just want to know what kind of bacteria is giving me this illness!”

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@Anna as I have said already in this topic, identifying the causes of schizophrenia,
is a significant step towards the solution.
If we can identify what causes the illness, we can then zero in and try to treat the cause.

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I never said it wasn’t important. But once we find out the cause, we want a treatment for that cause yes?

Hi @GentleSoul .
I am sorry that you are so upset.
Can you rethink your mindset?
It pains me to see your negative outlook about yourself.
Miracles happen. You might benefit from a miracle OR from a cure OR better treatments.
In any case try to be optimistic.

The main drawback of old age is reduced life expectancy.
However, I know of people who are in excellent cognitive, and physical condition at really advanced ages.

Hey sis twinkle star i fully trust stem cell and crispr…but i doubt it wont happen too soon…big pharma will push it availibilites to 100 yrs to 150 yrs…so i said its not good to hope they will reach to us anytime sooner…so i am sure it will take atleast 50 yrs to reach to us…

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@far_cry0 you can’t put a timetable.
Lets wait and see how things pan out.

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Pharma doesn’t have that power. The big pharma companies are actually investing in these technologies. Anyway the only real authorities who could delay it are the FDA and other regulatory agencies.

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Big pharma and fda are partners in crime

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What crime? They would love to give us (sell us) a cure. :slight_smile:

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The FDA is only relevant in the United States.
The research that might cure schizophrenia might also take place in other countries.
@twinklestars @far_cry0

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Not really, if they were, the drug companies would be able to get them to approve more drugs, and spend less on trials.

Yes, @Chess24 some country’s regulatory agencies are more liberal about new research and cutting edge trials.

I just checked clinicaltrials.gov and there are over 1,400 studies recruiting that study some form of cell therapy. They range from autism, to type 1 diabetes, kidney failure, heart disease, to, I’m not kidding, erectile dysfunction.

This is worldwide. There are trials in US, France, China, Vietnam, Iran, and many others.

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The only way to find the cause of sz is to find the cure. The cure will identify the cause.

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