I’m too excited about caplyta, roluperidone, karxt, ulotaront, etc… it’s like in just a few years I might be able to work and function like a normal person. They need to release these meds already!!! What new medication are you excited about?
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That failed phase 3 trials.
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I hear they applied for approval in august anyway, I think it should be available within a year or so…
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Caplyta is out in the USA. Many patients did not like it. The others we have no control about at all.
Even some of the most promising new meds produced agitation in a minority of patients in trials. Quite a few patients withdrew from the short trials. There is no guarantee any of these will work on an individual long term.
Good luck when you are able to try one of these.
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Why so negative? If the new drugs work like they say they do, that would be a hugely positive thing… sorry im just so pumped
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I am trying to be realistic. No psychmed has ever worked on everyone. None of the new meds worked on everyone in the trials. Do not count your chickens before they hatch.
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None of them. I’ve spent the last thirty years mostly feeling like Charlie Brown trying to kick Lucy’s football when it comes to new meds. Nothing has really blown my socks off. The only thing that did was a supplement and not a med. I generally don’t fixate on new meds for this reason.
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what supplements you think are good for me as a Schizophrenic that might help?
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Fair enough, we will see if the new ones are any good soon enough
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Try not to get your hopes up too much, only to be let down.
They say positive stuff about all new drugs, saying no side effects and stuff. When they all turn out to be crap for most people.
I’m fine on micro dosing Abilify, and my fortnightly risperidone injection.
But they could still turn out to be good, but going by what I’ve learned since having schizophrenia the drugs come with lots of side effects and then you gotta sort them side effects out and all that crap.
I’ve read the horror stories of Caplyta, they scare me more than a horror movie. One girl couldn’t stop laughing for months, just chronic laughter! What the hell must it be doing to the brain?
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Well everyone has a unique DNA plus factor in the Genes and all it will take many years before medications are improved. What I don’t understand is why it is that vitamins and holistic systems seem to truly cure people vs. medications approved by FDA on their own in my own personal experience find the source cause and treat a person with holistic medicine is helpful but does not always cure the source issue either. One cannot exist without the other like we all have countries that must co-exist, our bodies are eco-systems where-in treating the brain you must also treat the side effects. the health and physical body, and the mind–mental state or thoughts through good behaviors.
An improved healthcare system would spend more time with patients, have an advocate to bridge the gaps and barriers, be in the US subsidized by the federal government in reparations for the damage they have done through Greed, Capitalism, and their own short-comings often by design. If you get vitamin D through a capsule bought at the store it can be just as effective as a vitamin D prescribed by doctor but I would trust the one prescribed, and then to go further if you can get vitamin D from the sun or from organic food it can be even more effective. You could start seeing food as medicine too.
My lifestyle changes are improving everything. Start seeing everything as affecting your genes, your traits, future thoughts and behaviors like food as medicine and also as survival, if you want to be comforted choose echinacea tea instead of a donut ie choose something non-toxic for your biology. And if you can’t make major changes or afford that kind of adjustment, there is nothing wrong with adding supplements approved by your psychiatrist first to the regimen.
There will never be a magical pill or quick fix that will cure schizophrenia. But I believe vitamin B4 and B12, Folate, Zinc, D for depression, natural sunlight, the right amount of oxygen and detoxing from oxidative stress caused by tobacco smoke, reversing cellular damage through medicines like Green Tea and hydration, and oxygen therapy, and all these things make major improvements to ones own mental health.
My theory is that schizophrenia is mainly an issue with white matter loss, nerve signaling, and learning to heal and restore/repair/rewire the signals–
I would speculate my personalized cure for schizophrenia would be: Strong tea of Sassafras and Ginseng, Rose, White Willow Bark, spa or sweat lodge to sweat out cellular damage etc, elderberry (good for immune and throat health) meditation practice Yoga, Ginkgo (helps blood flow to the brain) CBD or Medical MJ (psychoactive so when used in small amounts at the right time can re-wire neuronal patterns) but only in tincture taken at certain times of meditation repeated over months and months. I plan to do this under the approval of a psychiatrist in the future not sometime soon but the reasons for this are both holistic and founded in biological science. Certain herbs are the basis for our medicines today. White Willow Bark is the basis for aspirin, tree bark was originally used for headaches, sassafras is anti-cancer and restores cell damage, rose and elderberry help with heart and throat and emotions anyways. there is a cure, it just takes a lot more and is a lot more expensive—and also not everyone can be cured by these techniques so its good to have a one-size fits all model but its not the only answer.
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All I’m saying is there are plenty of “new” drugs that are being used widely right now. Think about latuda, abilify injectable, vraylar, invega, etc… If these newer medications are just as good, I’d say that would be pretty awesome and I’m really hopeful for the future.
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I spoke to someone awhile back who took KARxt in the trials. He said he felt it made him irritable but yes got rid of negative symptoms. I’m trying to see how to interpret this drug with limited knowledge. My guess and it is not an educated one is that it acts similar to an “Enema “ on the body of all things on stimulating and holding the vagus nerve and releasing acetylcholine and creating a “good stress” on the body. I though… have no idea how a “pill” could replace something that is similar to a coffee enema or enema
Again, I’m just guessing
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I’m not sure, I’m just basing most of my knowledge from information on the website of each drugs manufacturer. It’s some pretty interesting stuff. The only way we’ll know if it works is if we try it ourselves. I’ve seen caplyta have some stellar reviews for some people.
Wow did not see irritability as a listed side effect. Interesting. I’ll add I think it reduces dopamine in certain brain areas (mesolimbic pathway) without effecting dopamine in other pathways. Hence, lack of traditional ap side effects (movement disorder, weight gain, prolactin increase).
I’m on Latuda, it wasn’t available when I was diagnosed, I wish it was, and I wish I was put on it sooner than I was, it’s a newer one relatively speaking and got me back to “normal” so I can understand your desire to try meds that haven’t been released yet in the hopes they’ll help.
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The ones I don’t have to take
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@idk516
The ratings on Caplyta are more negative than positive. The Reviews are more positive, but many of the Reviews are for bipolar, not schizophrenia.
The same guy said he has been taking Roluperidone in combination with RL-007 and felt a huge difference between that and KARxt he said it’s the best thing he’s ever tried. Don’t know if he is still doing Rl-007 though
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Take what people said on Reddit with a grain of salt, clinical trials are usually more accurate, for example, people complained about all kinds of side effects for taking covid vaccines but now the technology is being used to create other vaccine for other illnesses
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