Have you tried niacin for negative symptoms of schizophrenia?

I find that large doses of niacin return a lot of my emotions back from being too flat! Just putting it out there! (this is for negative symptoms of schizophrenia)

You have to redose every 4 hours though, the internet says the life of niacin only lasts 4 hours?

That’s interesting it’s eliminated in 4 hours.

I take 500mg daily for positive symptoms. It feels like taking it once a day is enough to give a physiological effect that lasts at least 24 hours in my experience.

I notice just recently it took an extra hour to kick in. You might need to dose effective from previous dose so it kicks in then at the correct time.

High doses of niacin available via prescription can cause:

  • Severe skin flushing combined with dizziness
  • Rapid heartbeat
  • Itching
  • Nausea and vomiting
  • Abdominal pain
  • Diarrhea
  • Gout
  • Liver damage
  • Diabetes

Serious side effects are most likely if you take between 2,000 to 6,000 mg of niacin a day. If you think you might have overdosed on niacin, seek medical attention immediately.

If you have liver disease, peptic ulcer disease or severe low blood pressure (hypotension), don’t take large amounts of niacin. The supplement has been linked with liver damage, can cause hypotension and might activate a peptic ulcer.

Taking niacin also might worsen allergies, gallbladder disease and symptoms of certain thyroid disorders. If you have diabetes, niacin can interfere with blood glucose control. Use niacin with caution if you have the complex form of arthritis gout. Niacin can cause an excess of uric acid in the blood (hyperuricemia), putting you at risk of gout.

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Interactions

Possible interactions include:

  • Alcohol. Taking niacin with alcohol might increase the risk of liver damage and worsen niacin side effects, such as flushing and itching.
  • Allopurinol (Zyloprim). If you’re taking niacin and have gout, you might need to take more of this gout medicine to control your gout.
  • Anticoagulant and anti-platelet drugs, herbs and supplements. These types of drugs, herbs and supplements reduce blood clotting. Taking niacin with them might increase your risk of bleeding.
  • Blood pressure drugs, herbs and supplements. Niacin might have an additive effect when you take blood pressure drugs, herbs or supplements. This could increase your risk of low blood pressure (hypotension).
  • Chromium. Taking niacin with chromium might lower your blood sugar. If you have diabetes and take niacin and chromium, closely monitor your blood sugar levels.
  • Diabetes drugs. If you have diabetes, niacin can interfere with blood glucose control. You might need to adjust the dose of your diabetes drugs.
  • Hepatotoxic drugs, herbs and supplements. These drugs, herbs and supplements, like niacin, cause liver damage.
  • Statins. Research indicates that taking niacin with these cholesterol medications offers little additional benefit when compared with statins alone, and might increase the risk of side effects.
  • Zinc. Taking zinc with niacin might worsen niacin side effects, such as flushing and itching.
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Big fat nope for me. Learned my lesson with the curcumin.

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I tried it for a while, but I had a really weird reaction! Every time I’d take niacin, a couple of hours later, I’d get really, really hot, nauseous to the point of throwing up, and my blood sugar would skyrocket to the 300’s! Every. Single. Time. I’m a type 1 diabetic, for context, regarding the blood sugar spike.

It was super weird. I haven’t heard of that happening to other people. I had to stop it, obviously.

I am glad that it works for you, though!

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I took like 3 to 5 grams of niacin everyday for about 3 years. Eventually my stomach wouldnt accept even 500mg of it and id throw up bile.

Also it raised my liver enzymes a fair bit which my doctor was concerned about.

So be careful you could wreck your stomach lining like me.

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Good to know. I’m a little afraid of side effects so I’m sticking to 500mg daily. That’s the maximum recommended dosage from the supplement industry. I wouldn’t use it unless it gave me a major benefit in calming down intrusive thoughts.

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It calmed down the intrusive thoughts for me so far. I know if I don’t time the dosage correctly it can come back and I basically loose capacity and have to sick back and take it easy…I reckon niacin is amazing because I can enjoy music more and play video games!

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Yeah theres a Dr.Abram hoffer theory roaming around the internet so thats where the high dose niacin idea was found for me.
As we know when were desperate we will try anything

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I suggest no one take more than recommended dose. Niacin is one of those supplements that can be dangerous.

Don’t want anyo e here to suffer needlessly.

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Yeah, I actually read a book he wrote. I think there is something to it for some people. Maybe not a cure, but a good add-on theraphy. But yeah, the problem is high doses can possibly give bad side effects.

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Yeah fair enough. I’m trying a lower dose to see if that is the same level. I’ll report results in 1 hour.

Fell asleep lol but yeah it worked

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The negative symptoms went away once I switched to Lithium monotherapy.

In the 1970’s I called up Dr. Hoffer in NYC and made an appointment to see him. He was a little man with great big hands. He gave a lot of OTC stuff to take.

In the end, I do well. Actually, I look young for my age. That is, I’m 72, and I look like I’m 67. Big woop!

But I don’t take any more niacin.

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