I don’t know why the online information I’ve found for antipsychotics and brain inflammation is so confusing.
Does anyone suspect whether Haldol or other first generation antipsychotics tend to reduce brain inflammation?
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i think they have part in brain damage like dementia and other brain related diseases
but that is just my opinion
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So, you think it increases brain inflammation?
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@Clint both inflammation and shrinkage
its showing up more now that people like us are living so much longer
just like sports like football and soccer and other head to body contact sports
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Then I should have brain inflammations because I’ve used Clopixol depo for 26 years in doses from 300 mg weekly to 500 mgs every 3 weeks. And I don’t think that’s the case for me that I’ve got inflammation.
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There you go! Anecdotal evidence. What’s wrong with that? Isn’t that one of the things this forum is good for?
Thanks for the reply.
I, myself, see people around me getting headaches from apparent brain inflammation. I’ve been on Haldol, and haven’t gotten such headaches.
Also, cocaine seems to increase dopaminergic activity, and lead to inflammation in the brain’s glial cells. Couldn’t suppression of dopaminergic activity have an opposite effect?
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I was on heavy doses of old style APs for some time. I had to have head scans done a while back. My brain is the correct size for my age and I test in the upper percentiles for function for my gender and age group.
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Aha! Cocaine, which stimulates dopaminergic activity, may cause inflammation in glial cells, while crazy amounts of Haldol, which suppresses dopaminergic activity, may cause a reduction in the number of glial cells.
I think I’m getting warmer.
“Further examination revealed a reduction in the number of glial cells; a similar postmortem finding in schizophrenia brains previously had been attributed to the illness.”
Sleuthing by a guy with ZERO medical qualifications:
Bingo.
Haldol → less glial cells
Glial cell damaged by Covid release cytokines that “exacerbate” neuroinflammation.
" Although their mechanistic role in neuroinflammation has not been fully understood, glial cells, such as microglia, astrocytes, and oligodendrocytes, mediate initiation and amplification of the CNS inflammation (39). The alteration in BBB permeability leads to the recruitment of immune cells into the CNS, promoting microglial activation. Activated microglial cells induce the production of cytokines and chemokines, resulting in the activation of astrocytes. Subsequently, activated astrocytes release more cytokines and chemokines that exacerbate neuroinflammation (58)."
I think that sucker causes much more inflammation than conventional antipsychotics so I use stevia instead of sucker.
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"Parkinsonian Neurotoxins Impair the Pro-inflammatory Response of Glial Cells"
I think it would be a bit ludicrous to argue that Haldol is not a “parkinsonian neurotoxin.” I think the standard way of specifying only some parkinsonian neurotoxins would have been prefacing the title with the word “certain,” or “some,” or something similar.
Aha! This may be why they didn’t specify only certain parkinsonian neurotoxins:
From the article I quoted last:
“These results show that the response of glial cells to a pro-inflammatory challenge is altered in the presence of toxins inhibiting mitochondrial respiratory chain activity, suggesting that the glial immune response is impaired by such agents.”
And, from the next article I’m quoting:
“Haloperidol induces hypofunctional effects on mitochondria in vitro… c Maximum respiratory capacity.”
Thus, Haldol appears to be one of the “toxins inhibiting mitochondrial respiratory chain activity,” and thus brain inflammation promoted by glial cells.
So, if doctors who were keeping up with these journals were aware that Haldol reduced brain inflammation promoted by glial cells around January 10, 2019, did the smartest doctors inject their Covid patients with 1 mg of haldol daily if they got a headache from brain inflammation?
1 mg of haldol daily is often given in hospitals just to help patients sleep, as I understand it.
“For mitochondrial respiration parameters we found that olanzapine, haloperidol and risperidone significantly decreased basal- and ATP-linked-OCR, while lithium significantly increased these parameters. Clozapine and risperidone significantly decreased mitochondrial reserve capacity OCR. Olanzapine and risperidone significantly decreased mitochondrial maximal respiration. VPA and perphenazine did not affect any mitochondrial respiration parameter.”
So, it may not be just Haldol. Very interesting.
My doc warned me about the death of glial cells from having psychosis untreated. Really worries me. He said having psychosis kills them off. I’m just concerned as ive been in and out of hospital with psychosis for a decade. So I don’t know what the best thing to do is. As aside this family members have parkinson disease. And I seem to have a similar body type. I don’t know if this makes sense though as my genetic expression might be different. Just I seem to also have personality quirks that are similar to males in my family with the disease.
Just I find atipsychotics cripple me physically. I’m very weak on them, get the shakes, loose balance. And one arm swings when i walk naturally but the other is still, without motion. Always worries me. Since the doc has lowered my meds my arms are normal, I’m not weakened, and don’t loose balance. But I struggle with motivation. I’m just worried as my risk of psychosis is high. But I can’t cope with being on very high doses of antipsychotics. They cripple me. So I can hardly move. For instance, get out of bed etc. It’s really awful for me.
I’m just thinking all I can do is as quickly as I notice changes up my meds again. Just the warning signs are hard for me as it’s rapid onset when it happens. So probably nothing I can do. Catch 22.
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Ouch. 
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Hmmm. So, since the Haldol shortage of 2018-2019 I’ve been concerned about Haldol being discontinued, and me having nothing similar to replace it with.
Then, I look at the structural formulas of Lumateperone and Haldol from Wikipedia:
That looks like the same molecular structure on the left side! Although a ball and stick model might reveal something like that which they do for structural isomers. I saw something like this before, when comparing Geodone and Latuda.
I guess I know what I might be paying for if they stop making Haldol again.
Or maybe I could switch to modified perphenazine if BL-1020 is reactivated.
If the studies above came to correct conclusions, maybe that will reduce any parkinsonism I may have. They say Gaba might also have something to do with Parkinsonism, but I don’t have medical qualifications, so I don’t know these things.
https://www.amjmed.com/article/S0002-9343(96)00381-6/fulltext
Maybe I’ll ask my psychiatrist about trying perphenazine to reduce my possible parkinsonism, or keep it from progressing further.
@jayster : You seem to have indicated in the past that you have some experience observing the effects of Perphenazine. Do you have any opinions you would like to share about perphenazine and avoiding Parkinsonism?
Would others like to share some thoughts?
Hmmm. A little off topic. Gaba and smart phone addiction: