Glycine for sleep

@DelusionalSandwich posted this thread:

So I decided to order some Glycine after reading his recommendation and it arrived today, a week early. So tonight I am going to give it a try before bed, see it if help me sleep.

I don’t know what to expect. I have had insomnia since quitting olanzapine. I was reading and they think the mechanism of action for sleep caused by olanzapine is due to olanzapine’s interaction with serotonin receptors. Glycine works with serotonin so perhaps I will find it helpful.

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I’ve been using glycine off and on for a few days, not sure how it works for me yet, but I hope you find relief with it.


Im thinking of supplementing glycine! I will do more research. Thank you for posting!

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I take magnesium glycinate for relaxing. Does seem to calm your mind.

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@Headspark You are probably still asleep… :smiley: I hope it worked for you.

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I tried it last week, and maybe it doesn’t go so well with abilify. I just felt “odd” while taking it.

But I find that abilify doesn’t go so well with lots of supplements (e.g. fish oil, Nac)

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Well last night I took the following…

800mg of gabapentin
7.5mg of Zopilcone
1500mg of Glycine then another 1500mg of glycine 5 hours later

I went to bed at 11:00pm and woke up at 4:00am to pee. I took another 1500mg of glycine and went back to sleep, woke up at 8:30am. Usually once I wake up that’s it, I am up, but last night I was able to go back to sleep.

I do feel better rested right today and I attribute that to the glycine. Sleep on Zopilcone alone is not a very good sleep and rarely lasts longer than 4-5 hours. I did some reading and there are 4 stages of sleep but sleeping pills like zopiclone screw around with those stages, the technical term is altering your “sleep architecture”. Gabapentin and glycine are good for your sleep architecture which I think is why I feel good this morning.

I will continue to take glycine and see if it really works or if tonight was just a placebo effect, but so far so good.

@Natron I can’t take magnesium supplements, last few times i tried I developed akathisia like symptoms, I lie in bed and I can’t sit still, I feel like sh*t, it’s brutal and lasts about 3 hours until the magnesium passes through my system. I have debated about trying it again because it has been a year since that happened, I do have some magnesium glycinate here at home.

@everhopeful I can’t take fish oil like omega 3’s, they make my body feel like it is burning up.

@labratmat Thanks man! I think it did work, but I have to try it for a week before I know it really works or it is just the placebo effect… But I feel really good right now.


I’ve been taking glycine for about a week, and I already noticed the difference. My sleep is better, so my head is clearer in the morning. What I like about it, is that it is a natural substance (amino acid) No more chemicals

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i take like 30g of glycine some days

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30g!!! My pills are 500mg. I’d have to take 60 of them!

I didn’t know you could go that high.

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its not really necessary to take 30g but i tried it after reading about its nootropic properties and how doses in that range can reduce sz negative symptoms

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I’ve been on Clonazepam for sleep for a week now. No more zopiclone or gabapentin…

The clonazepam on average puts me to sleep for about 6 hours, zopiclone alone was about 5 hours, so it is an improvement. The sleep quality of clonazepam is a little better than zopiclone too.

However mixing clonazepam with glycine really improves sleep quality. I took 5000mg of glycine the last few nights, 100mg l-theanine and 1.5mg of clonazepam and I feel better than I have in a long time. I may even try higher dosages of glycine and l-theanine, I read a study on schizophrenics where they gave them 17000mg (17 grams) and it really helped with negatives. I also read that glycine only passes the blood brain barrier when taken in high quantities. It helps with sleep by affecting serotonin.

I just ordered 2lbs of glycine powder and 200mg extra strength l-theanine capsules. If this continues I think I have my sleep problems much more under control…not perfect, I would like to be able to fall to sleep naturally without chemical help and sleep for 8 hours uninterrupted, but the last couple days are the best it’s been in months.

I’ve had so much more energy and vibrancy about me the last couple days.

Thanks @DelusionalSandwich for mentioning glycine.

Drink Tulsi tea around 6 PM and you will be able to fall asleep at night and also helps to dream at night.

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