mpairments in social activity began 12 years before hospitalization for the illness.
Clinicians and patients would benefit from the identification of early schizophrenia symptoms. To learn more about early symptoms, researchers cross-referenced a national hospitalization database in Israel with data from mandatory psychological and functional assessments of draft eligibility in 723,316 Israeli males aged 16 to 17 (mean follow-up, 10 years).
The data provided pre-illness information about functioning in 3929 individuals who were eventually hospitalized for schizophrenia. The investigators compared 1659 of these individuals plus a matched nonaffected sibling with 167,616 well sibling pairs.
Social activity (ability to make and maintain friends), independent behavior (ability to make decisions and resolve conflict in interactions), and school/work functioning were correlated with each other. For patients, early impairments began in social activity and school/work functioning. Social impairments began 12 years before the first hospitalization and increased as hospitalization got closer, but deterioration paused for a few years preceding the 5 years prior to hospitalization. Independent behavior began to worsen 5 years before first hospitalization. Compared with controls, unaffected siblings of patients had much smaller impairments in social activity and school/work functioning; these impairments did not increase.
http://www.jwatch.org/na40058/2016/01/12/functioning-decreases-before-symptoms-start-schizophrenia