Elevated Levels of Plasma Phenylalanine in Schizophrenia: A Guanosine Triphosphate Cyclohydrolase-1 Metabolic Pathway Abnormality?

Phenylalanine and tyrosine are precursor amino acids required for the synthesis of dopamine, the main neurotransmitter implicated in the neurobiology of schizophrenia. Inflammation, increasingly implicated in schizophrenia, can impair the function of the enzyme Phenylalanine hydroxylase (PAH; which catalyzes the conversion of phenylalanine to tyrosine) and thus lead to elevated phenylalanine levels and reduced tyrosine levels. This study aimed to compare phenylalanine, tyrosine, and their ratio (a proxy for PAH function) in a relatively large sample of schizophrenia patients and healthy controls.


I believe the food we eat, our body does not syntheses the amino acids, accurately, if we were tested for all of amino acids, vitamins etc. we can treat our condition with just supplements. But it will cost the government thousands of dollars on every person to do those kind of tests, they choose the cheaper road, antipsychotic. I have supplemented myself with amino acids and i haven’t had hypnopompic hallucinations yet.