More evidence for glutamate dysregulation in schizophrenia

evels of glutamine, but not glutamate, are elevated in the dorsal anterior cingulate of patients with established schizophrenia, say researchers.

Most previous studies have measured combined levels of glutamine and glutamate, rather than assessing their levels individually, although one study that directly measured glutamate found increased levels in the associative striatum and cerebellum of first-episode psychosis patients.

“Glutamine is the principal metabolite of synaptic glutamate and increased presynaptic release of glutamate could result in greater concentrations of glutamine,” say lead researcher Juan Bustillo (University of New Mexico, Albuquerque) and co-workers.

Interesting, cheers for post