Editorial: Community series in novel antipsychotics within and beyond

Psychiatric disorders are a heterogenous group of conditions characterized by various symptoms and complex underlying pathological mechanisms (1). Aiming to simplify diagnostic and treatment strategies, current definitions of psychiatric disorders are rather categorical, thereby overlooking their inherent complexity (2). To give an example, according to the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5) (3), schizophrenia is diagnosed based on the presence of two symptoms out of five, meaning that two patients with the same diagnosis can exhibit a completely different symptom profile (2). This leads to the question: how should we treat patients with the same diagnosis but different symptomatology? A solution for this puzzle is a symptom-based treatment which refers to the notion that psychiatrists make their treatment decisions primarily based on the actual symptoms the patient experiences rather than the diagnosis itself (4). This transdiagnostic approach helps to make treatment decisions that are more personalized and therefore might have an increased likelihood of being effective (4).