“Novel mechanism-based treatments are also likely to be developed. He stated that one such therapy might be kynurenine aminotransferase II (KAT II) inhibitors. Fluctuations in brain kynurenic acid (KYNA) levels bi-directionally regulate extracellular concentrations of glutamate and other major neurotransmitters. Even minor elevations in KYNA during early brain development or later in life, impair cognitive functions. Astrocytic KAT II is a major determinant of the rapid formation of neuroactive KYNA in the mammalian brain. Acute down regulation of brain KYNA, which is now possible with several recently developed KAT II inhibitors, has been shown to improve cognitive function in preclinical research. Testing of the potential pro-cognitive effects of KAT II inhibition in humans is expected in the not-so-distant future.”
@far_cry0, Glutathione is an NMDA agonist, that might be the key to conquering negative symptoms. I’m going to buy some tomorrow locally, I can’t wait a month for my shipments to come in.