I’ve been feeling noticeably better on this batch of buproprion. Not sure if they changed the formula
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that means it’s working is all…it’s the identical same as always.
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There are some differences between generics but most people won’t feel the difference
I recently switched from Solco brand risperidone to Zydus brand and I definitely feel a difference.
The Zydus brand is more activating than the Solco brand.
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Each batch differs in the percentages of the different isomers of which it is comprised.
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If they use the same method why would it vary? They have to be using a standardised procedure.
I know this was an issue but this is LA forumlation Bioequivalance and therapeutic equivalence of generic and brand bupropion in adults with major depression: A randomized clinical trial - PMC
Unless the company states as such themselves or you have personally carried out the commercial synthesise procedure yourseld then you couldn’t know the isomer yields in actuality. I don’t know the synthesise procedure so it’s fair to say they could but if they actually did vary significantly then fda could investigate. So its more reasonable to operate under the assumption that they don’t. It’s pharmaceuticals
I’m not a scientist but I’m sure there’s rigorous testing to standardize the medications.
For example gluten free food they test the food to analyze that it has less than 20 parts per million (ppm) of gluten.
I imagine they do a similar ppm or similar analysis of each batch so they know what’s in it almost exactly.
That’s just my opinion tho again I’m not a scientist
Why would they use the same method? I imagine pharmaceutical companies try to keep their methods secret. Generic drugs are made by the competition, don’t you think?
Firstly batches implies that it is the same brand medication. Even where it is generic it lists the pharmaceutical company which made the product. Further if you are buying it from the same pharmacy it is reasonable to assume that more often then not you are buy the same generic medication as you did last time. I think it is also reasonable to assume that same pharmaceutical company are using the same if not idential synthesise methods across all their facilities. So interbatch variance from the same company would be low. They are likely making it all out of the same facility using the same method.
Generic vs brand is different. There is an element of trade secrecy in this context. There are many novel routes of synthesise for chemicals. At scale, the ability to both mass produce and the cost of raw materials become limiting factors. Therefore the amount of synthesise methods that you could select from in commercial application would severely diminish. By the time that the medication becomes generic and has been on the market for multiple decades the majority of the commercial synthesise routes would be known. This isn’t exactly going be a secret because of the money involved in pharmaceutical companies means that they could do extensive oppo research.
I would imagine that there is a handful of commercial synthesise methods. The exact step by step is secret but I doubt the overarching methodology is. There are a small number of well funded companies operating in this space they would only be about to keep things a secret for so long before it was in the commercial interests of their competitors to know. Assuming that more advanced/different synthesise method confers a commercial advantage which it may not.
That aside different racemic mixtures of amphetamines is what patients adderal. It doesn’t make sense that the fda would allow different compositions of the generic drugs and still allow them to meet equivalence. They are standardised and they are the same because if they weren’t then the wouldn’t be the same drug.
How do you know each batch contains different percentage of isomers? To be vaild this information would have to come from a reliable source working in industry. If it were really the case I wonder what the fda’s stance on it would be?
Small chance it’s different if it’s the same manufacturer. Is it the same brand as last time?
There is a likelihood of it being a bit different between doses and manufacturers. Not all ingredients are the same quality which is why some doctors insist on name brand.
I have noticed a difference between name brand tramadol and generic. Not huge, but noticeable.
Several years ago there was a medication, I think it was actually Wellbutrin, that had a big media blow up because their different doses turned out to not haveany of the activie ingredient. I’m probably wrong on which med it was, I just remember it was one I was taking.
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Agree. I find the difference between brand zyprexa and generic to be huge. Brand zyprexa is like a much more heavy drug giving much more solemness than generic. At least the generic I am on.
From this discussion I sparked an insightful conversation with my pharmacist. Where I am because of the regulation standards generic and brand are equivalent. I always thought people who raised this discussion were crazy. But it actually depends on the regulations in place you live. Where there is substandard health care and or lack of government oversight/regulations of medications then brand and generic equivalence does not necessarily hold true.
More generally the priciples apply, I know in some parts of the world brand products are imported at cost and preferred due to issues with quality control.
Further, under lack of regulation oversight there would be a myriad of way you could create cheaper products at lower cost. Including the example were you either put no active ingredient in the medication or skip in house equivalence testing to reduce cost.
This was in the USA. There’s supposed to be a lot of oversight,but shady things still happen.
One thing that I find confusing is that some of my heart meds change colour and shape from one scrip to the next. That’s because the pharmacy gets the same one from different manufacturers depending on price and availability. I’ll be like, “it used to be pink - wtf?” I wind up phoning the pharmacy to make sure I got the right pill and I did, it’s just that different generic manufacturers have different appearances for the same meds.
Bupropion smells really bad when it is fresh.