Do all sz medicine cause weight gain or is there any difference from one sz med to another in terms of weight gain?

I have been on zyprexa/ olanzipine for over a year now.

Anybody on this med ? How do you feel?

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The majority of them do.

I’m on Caplyta, which is not supposed to be a weight gaining med, but I’ve gained 15-20 pounds since I’ve been on it in July.

I think what it does is make me want to eat, and not care that I’m overeating, not that the medication puts weight on all by itself.

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Yes I agree with you on this.

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I think Zyprexa, though, puts weight on you whether you overeat or not.

There definitely are differences between the meds as far as weight gain. If you do an internet search you should be able to find articles that compare the meds.

Antipsychotics with a lower risk of weight gain are:


The only one I know that definitely doesn’t is Geodon. When I was on that, I lost weight.

I should go back on it.

Can you tell me how zyprexa/ olanzipine does in that regard?

From that same article:
" Some antipsychotic drugs are more likely than others to cause weight gain. The risk is highest with clozapine (Clozaril, FazaClo) and olanzapine (Zyprexa)."

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So I am currently on olanzipine and it has helped me a lot with my depression but I did gain a lot of weight … So does it mean I can’t reverse the damage while still being on olanzipine?

Can you please tell?

I’ve never been on that one, so I don’t know if it’s possible to lose weight on Zyprexa or not.

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I don’t have a definitive answer for you. I suppose that it is POSSIBLE to lose weight on any AP, but just based on the proclivity to gain weight on that particularly AP, I would guess that it would be harder.

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My weight was highest on Zyprexa over 300lb but my psychiatrist told me Clozapine is even worse.


I gained 85lbs in 6 months on Zyprexa but I was on Clozapine for 3 years and I lost weight on it. Now that I’m on it again I have gained about 40lbs over the course of a year


I was on 40mg for 17 years. I was fat and unhealthy. At my worst I was 240lbs, it gave me diabetes, I had high cholesterol, triglyceride and liver enzymes. My doc told me my big gut was putting me at risk for a heart attack. I was in bad shape on that stuff. I also slept all the time and had no energy or motivation to do anything. It did prevent my psychosis but I paid a heavy price for that, nasty drug imo.

I tried diet, exercise, gym memberships, workout tapes, nothing worked to lose the weight. It killed my metabolism and made me hungry all the time. I couldn’t lose a pound on it. But once I quit the weight just melted away on its own without any effort.

I slowly transitioned from olanzapine to 60mg lurasidone (latuda) over the last 2ish years. I’ve lost all that weight, I’m a healthy weight for my height (BMI). My blood work is perfect, and I now have blood sugar levels consistent with a pre-diabetic Getting off that stuff was the best thing to happen to me since I developed schizophrenia…

The only problem is that when I finally quit (almost 6 months ago) I developed very severe withdrawal insomnia that still plagues me, its absolutely brutal. I have to take 1.5mg of clonazepam to sleep, I can’t sleep without it, at all.


Thank you.

Your review helps me a lot.

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I gained weight on Olanzapine. I never felt full after eating. I’d over eat daily. Even so far as eating at midnight.

I switched to Caplyta and have been steadily losing weight. I like that part about it however I have symptoms from time to time.


I feel more normal on zyprexa.
At higher dose sedating.

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I’m so jealous. As I posted above, I have had the opposite problem.

I lost weight on Geodon, and I’m tempted to go back on it for that reason.

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