Commonly Used Antihypertensive Drugs In The Treatment Of Schizophrenia Or Dementia? Let’s Talk About Kynurenic Acid

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wow ! Thanks @firemonkey!

So these ACE inhibitors may help with KAT II inhibition as well! …Nicely spotted…

“Since KYNA is a glutamate receptor antagonist, we analyzed the effect of
three ARBs: irbesartan, losartan and telmisartan on KYNA production in
rat brain cortex in vitro.”

I have experimented with anti hypertensive drugs (given that a lot of early anti psychotics were in fact anti hypertensive ) and found some to be quite helpful - the calcium channel blockers for example and even some beta blockers. But never tried with the ACE inhibitors.

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http://www.psychiatryadvisor.com/schizophrenia-and-psychoses/schizophrenia-telmisartan-effects-decrease-panss-score/article/689540/

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Thanks @twinklestars and @firemonkey - time to print out these studies and trek over to my doc to try and get him to prescribe low doses to try out. If I cant get him onboard may have to get a mate in Thailand or India to get me a few tabs!

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