I read that caffeine decrease Clozapine metabolism.
The article posted was only about one case and they were asking for more studies to clarify that possible conclusion of extreme toxicity. I suggest maybe asking your doctor and researching more.
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@GrayBear @cdwithdcs Did your pdoc prescribed Clozapine fast? Mine said she has to do paperwork as its a special regualted and restricted medication.
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“These results suggest that caffeine in daily doses of 400–1000 mg inhibits the metabolism of clozapine to an extent that might be clinically significant in certain individuals.”
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I take 400mg sometimes a bit more. I guess I don’t have to worry.
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I keep reading that Clozapine is the king of antipsychotics and most effective lol
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I’ve read and been told by pdocs the same thing. But there are a lot of restrictions on it, possible serious side effects, and monthly blood tests. They wanted to put me on it but I refused. I would consider it if I was desperate and nothing else worked, but I wanted to try other meds before that one.
But you’ve been mentioning your negative symptoms ever since I joined this forum so it may be a good alternative for you…I guess if it doesn’t work you can reinstate your current meds, and if it does work that that would be a great thing.
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I am not sure. I was prescribed when i was in the hospital. 
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Hmm I don’t remember. I’ll ask my fiancée when I talk to her next.
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She wasn’t sure, @Aziz. Sorry.
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I don’t know, but I know caffeine especially energy drinks and maybe even smoking cigarettes (nicotine) reduces the effectiveness of meds and scrambles my brain and stuff.
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My pdoc only informed me about the interaction with smoking. Didn’t know about coffee. I wouldn’t worry too much about it!
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