Levetiracetam, sold under the brand name Keppra among others, is a medication used to treat epilepsy. It is used for partial-onset, myoclonic, or tonic–clonic seizures and is taken either by mouth as an immediate or extended release formulation or by injection into a vein.
Case presentation: We present the case of a 23-year-old female patient suffering, since the age of 14 years, from a fluctuating paranoid-hallucinatory syndrome with formal thought disorder, fear, delusions of persecution, auditory, visual, and tactile hallucinations, as well as negative and cognitive symptoms. Laboratory measurements showed increased titers of antinuclear antibodies (ANAs) in the context of ulcerative colitis. While there was no clear history or evidence of epileptic seizures, the EEG showed generalized 3 Hz polyspike wave complexes. Under treatment with levetiracetam, the symptoms disappeared and the patient was able to complete vocational training.
I found levetiracetam being mentioned in this 2020 review on “hippocampal hyperactivity” in schizophrenia:
The potentially central role of hippocampal hyperactivity in causing the hyperdopaminergic state in schizophrenia and resulting aberrant assignment of salience provides a rationale for attempts to reduce hippocampal excitability and synaptic glutamate release. Partially, this might be achievable by re-purposing existing drugs, for example by low doses of levetiracetam which reduces presynaptic transmitter release (Surges et al., 2008; Meehan et al., 2011), enhances GABAergic signaling (Wakita et al., 2014), and ameliorates age-related hippocampal hyperactivity (Haberman et al., 2017) (currently tested in clinical trials NCT03034356, NCT02647437).
alot of people take piracetam, phenylpiracetam, aniracetam, etc as nootropics to enhance cognitive mental performance. i read levetiracetam is different im some ways to those ones but it is a prescription med i guess and not a supplement you can buy online
This is really exciting. Could a psychiatrist prescribe this now? What do you think the timeline looks like in terms of psychiatrists actually using this?
This topic is about an entirely different drug. Lamictal is also known as lamotrigine. And everyone reacts differently to every med. Please refrain from telling people to try/avoid certain meds just because they did/did not work for you.