Has anybody have tried amisulpride ? Did anyone had problems with prolactin, EPS symptoms and qtc prolongation while being on this drug ? How was your experience like while being on this drug.
I’m thinking about asking my pdoc for this.
I’m gaining alot of weight on clozapine and valproate combination. Also I’m sleeping 12-13 hours at night on clozapine. Stephen stahl book and other pubmed studies say amisulpride is less likely to make u gain weight [1]. And amisulpride seems to be as effective as olanzapine in terms of reducing positive symptoms.
I was on sulpiride which is a typical but related to amisulpiride. It helped me for a number of years. I didn’t put on weight with it but I was smoking then.
Amisulpride increases prolactin but is not generally associated with weight gain, so I thought i might try it. Paliperidone/Risperidone/Quetiapine are effective but cause weight gain, with the first 2 antipsychotics causing extremely high prolactin levels. I have tried abilify before at max dose of 10mg, it didnt do anything for my psychosis at this dose, doses above 10mg was making me extremely lethargic - couldnt get out of bed.
