A list of drugs in development in 2016. Just hit CTRL-F and type in schizophrenia to find all current schizophrenia drugs.
http://phrma.org/sites/default/files/pdf/medicines-in-development-drug-list-mental-illnesses.pdf
[SzAdmin / Editor note: Some of the medications on this list have already been cancelled due to poor test results - such as the Forum Pharmaceuticals drug targeting cognition. ]
This post perfectly illustrates the fact that we commonly believe that progress in the cure of schizophrenia and other mental illnesses only depends on new antipsychotics and other medications while we could do drastically better with the plenty of existing and older molecules just with an earlier intervention BEFORE PSYCHOTIC TRANSITION. I think that this chem-centred attitude in public opinion is shaped by Big Pharma powerfull mediatic relays. In fact 50% of the job is all about cares organization&coordination : prevention is better than cure. This decisive stake consists in early detection of high risks cases during prodromal phase or even better premorbid. The earlier is the intervention, the better is the prognosis. Definition and application of efficient preventive procedures is probably the most important line of work for mental health care community for the time being. This matter should be considered by health authorities to be of tremendous significance.
I was mentally ill long before anyone noticed. It was easy to hide the symptoms.
If it wasnāt for antipsychotic I would have killed myself or become homeless. I think antipsychotic are absolutely necessary for a large percentage of schizophrenics. I do agree with you, early detection should be taught to teachers and in school.
I completely agree with that. I only think we can considerably OPTIMIZE the usage of existing antipsychotics arsenal. Personaly, Iāve been diagnosed very late when āthe crime was done and the gun was smokingā. My mother, who also suffers a form of bipolarity has had to wait decades before having the right diagnosis and appropriate treatment. I think pdocs are not very good in diagnosing : they could do better.
Iām sorry that happened to you and your mother. There are some terrible psychiatrist out there. But alot of them are fairly competent. Iāve had two psychiatrist and so far both have been great.
I even think that psychiatrists form a corporation of self-asssured, smug, arrogant and domineering people . Their power and ego blind their clear judgment, so they rarely reassess themselves, their diagnoses and treatments they propose. This is a personal feeling.
Prevention is important, but also difficult I think, for causes and early signs are so vague and hard to pin down for this particular illness, well currently they are.
How long does a noticeable prodrome last? Sometimes a couple of months, sometimes years. Whatās the age of onset? It differs quite a lot. 18-30 or so would catch most I suppose. Combine these two, and something like a yearly check-up might come to mind, each year within that period. Then thereās the problem that prodromal changes can be subtle, so a check-up might need to be quite thorough. Thatās a pretty big operation to have this whole age-group checked up each year. Of course, one can limit the group to high-risk individuals with known genetic predisposition because of their parents or siblings having sz. But at each step to reduce the scope of the preventive operation, there are going to be some cases being missed out on. Oh well, any increase in prevention is progress, doesnāt need to be a perfect score straight away.
Biomarkers would be great, and there is some news about new ones being discovered every now and then. Iām not quite up to date with that literature, but I donāt have the impression that the ones that have been discovered point to sure-thing schizophrenia later on. I get the impression that biomarkers and genes that are involved all have some predictive value, trends and percentages, associations and correlations - all can be used to narrow down the group to increasingly higher at risk individuals. But no litmus test that will tell whether itās going to happen or not. Please correct me if Iām wrong on this. But I sometimes wonder whether the fact that more and more genes are discovered āthat have something to do with itā is reason to be optimistic or rather pessimistic. In terms of prevention, the group to be monitored only increases with such discoveries it seems to me?. Thereās an interesting diagnostic tool with a pretty good predictive power called the EASE test/interview. Perhaps that can help narrow down the at risk population even further. In a later stage I suppose, because of time/resources that interviews take.
Do you have some links&infos about this test/interview?
The website:
An article:
http://europepmc.org/articles/PMC4219858
More can be found if you combine āEASEā with āanomalous self-experienceā. (EASE alone is not a very useful term when searching).
Im waiting for the a7 nachrs cognition meds, encenicline was a disappointment. Im impatient to have these drugs and min-101 out. Antipsychotics have done nothing for my only symptom alogia. Im also waiting on the new antidepressants which might have more efficacy forvnegative symptoms.
A7 nachrs + min 101 + new antidepressants = possibly symptom free me