Clinical Trials of N-acetylcysteine (NAC) in Psychiatry and Neurology: A Systematic Review

Summary:

…we find favorable evidence for the use of NAC in several psychiatric and neurological disorders, particularly autism, Alzheimer’s disease, cocaine and cannabis addiction, bipolar disorder, depression, trichotillomania, nail biting, skin picking, obsessive-compulsive disorder, schizophrenia, drug-induced neuropathy

Overall, NAC treatment appears to be safe and tolerable. Further well designed, larger controlled trials are needed for specific psychiatric and neurological disorders where the evidence is favorable.

More about N-Acetyl cysteine (NAC) for Schizophrenia
http://schizophrenia.com/?page_id=706

Source:

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NAC seems like a really good option but mucolytic effect makes me worry. Importance of mucus is underestimated I think. NAC would increase the risk of getting infections (especially the respiratory infections) because of its mucolytic effect. All in all, I would add some more links to this thread.

The clinical trial on human sz subjects

http://www.ncbi.nlm.nih.gov/pubmed/18436195

A case report
http://www.ncbi.nlm.nih.gov/pubmed/19735056

And this

The anti oxidant effect is really good; but I probably won’t use NAC because of its mucolytic effect.

Up until recently, I was a heavy smoker for almost 4 years. Taking NAC has made it easier to breathe. In fact, it worked really fast. I feel like I have more lung function.

It seems like there are some significant beneficial effects of NAC in terms of its mucolytic effect too.

I will test this out starting today!!

1g twice/day? 15

600 mg oncea day

I’m taking 500 mg once a day, a fairly low dose. I like it.

Is NAC different than Sarcosine??

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Yes, it’s n-aceytl-cysteine. They’re different, probably safe to take together, they work different ways.

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I am getting a good response to nac. Think my negative symptoms have improved.

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