The present study detected improvement in positive, negative, general and total psychopathology symptoms as well as cognitive performance with N-acetyl cysteine (NAC) treatment. It is also well-tolerated, safe and easy-to-use agent as an effective therapeutic strategy to improve outcome in schizophrenia treatment.
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N-acetyl cysteine (NAC) is a nutritional supplement widely available in most countries and on the internet.
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Acetylcysteine, also known as N-acetylcysteine (NAC), is a medication that is used for the treatment of paracetamol (acetaminophen) overdose and to loosen thick mucus in individuals with cystic fibrosis or chronic obstructive pulmonary disease. It can be taken intravenously, by mouth, or inhaled as a mist. Some people use it as a dietary supplement. Common side effects include nausea and vomiting when taken by mouth. The skin may occasionally become red and itchy with either form. A non immune ty...
Summary:
Z Sepehrmanesh, M Heidary, N Akasheh, H Akbari and M Heidary,
Progress in neuro-psychopharmacology & biological psychiatry , Nov 2017 07
Schizophrenia is one of the most disabling psychiatric syndromes with the prevalence of 1% in the general population. Despite availability of various antipsychotics, negative symptoms and cognitive impairment are difficult to treat. In addition antipsychotic monotherapy is not effective in most of these patients. Current evidence indicates the roles of glutamatergic system in this disorder. N-acetyl cysteine (NAC) also increases extracellular glutamate. This study was conducted to evaluate the clinical effects of oral NAC as an add-on to maintenance medication for the treatment of chronic schizophrenia.This 12-week, double-blind, randomized, placebo-controlled, clinical trial was performed to determine the effectiveness of 1200mg N-acetyl cysteine as an adjunctive treatment with conventional antipsychotic medications in 84 patients with chronic schizophrenia. The subjects were evaluated with the Positive and Negative Syndrome Scale (PANSS), Mini-Mental State Examination (MMSE), and a standard neuropsychological screening test. Data were analyzed with SPSS-16 software.NAC-treated patients showed significantly improvement in the positive (F=5.47, P=0.02) and negative (F=0.20, df=1) PANSS subscale. Also the general and total PANSS score of NAC group declined over times whilst it was increased for placebo group. Regarding cognitive functions, improvement was observed in some explored areas, such as attention, short-term and working memory, executive functioning and speed of processing. There was no significant difference between the 2 groups in the frequency of adverse effects.The present study detected improvement in positive, negative, general and total psychopathology symptoms as well as cognitive performance with NAC treatment. It is also well-tolerated, safe and easy-to-use agent as an effective therapeutic strategy to improve outcome in schizophrenia treatment.
FULL RESEARCH PAPER DOWNLOAD FOR FREE (Pdf) http://sci-hub.cc/10.1016/j.pnpbp.2017.11.001
2 Likes
I’ve started taking 1.2g in the morning for a few days now. Helps with hypnagogia.
1 Like
GentleSoul:
hypnagogia
Whatz this negative symptoms…
“Hypnagogia is the experience of the transitional state from wakefulness to sleep in humans: the hypnagogic state of consciousness, during the onset of sleep. Mental phenomena that occur during this “threshold consciousness” phase include lucid thought, lucid dreaming, hallucinations, and sleep paralysis.”
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Chess24
November 12, 2017, 3:55pm
6
@GentleSoul I love you…@firemonkey you’re a hero
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Nope. L-theanine and NAC for now. What about u?