Will New Antipsychotics for Schizophrenia Be Game Changers?

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Are they saying KarXT will be available ealry 2024?

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Only in the USA.

Hereā€™s what bing chatGPT had to say

According to the web search results, KarXT is an oral, investigational M1/M4-preferring muscarinic agonist in development for the treatment of psychiatric and neurological conditions, including schizophrenia and psychosis in Alzheimerā€™s diseaseĀ¹. It is the first potential new pharmacological approach for treating schizophrenia in over 50 yearsĀ² and may provide an alternative option for people living with the conditionĀ².

KarXT has successfully completed two phase 3 clinical trials in the United States, showing significant improvement in both positive and negative symptoms of schizophrenia without the common side effects of current antipsychotic therapiesĀ³ā“. However, there is no official information about when KarXT will be available in Europe. The company behind KarXT, Karuna Therapeutics Inc., has stated that partnerships would likely be essential to enter the European marketĀ³. Therefore, it may take some time before KarXT can be approved and distributed in Europe.

Source: Conversation with Bing, 25/09/2023
(1) KarXT ā€¢ Karuna. KarXT ā€¢ Karuna.
(2) Breakthrough potential treatment for schizophrenia | News | Wellcome. Breakthrough potential treatment for schizophrenia | News | Wellcome.
(3) Karunaā€™s schizophrenia drug succeeds in a second late-stage trial. Karunaā€™s schizophrenia drug succeeds in a second late-stage trial | BioPharma Dive.
(4) Novel anti-psychotic shows promise in Phase II schizophrenia trial. Novel anti-psychotic shows promise in Phase II schizophrenia trial.
(5) KarXT - Wikipedia. KarXT - Wikipedia.

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I think they are guessing KarXT availability 2nd half of 2024. No NDA application yet, and application takes 9 months usually.

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Wow, KARXt is good for cognitive symptoms as well. I didnā€™t know that.

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Does karxt block dopamine or is it different?

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it is an muscarin agonist, which influence dopamin etc. indirect

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My psychiatrist was right when she said that all the antipsychotics were the same.

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Doubt anything will beat clozapine because it can literally kill you

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I donā€™t think they are all the same, different meds affect different people in different ways.

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Yes thatā€™s true the experiences are all different but overall, generally speaking they all affect dopamine

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