Tried asenapine (Saphris) last night and

I woke up feeling completely stoned. I didn’t use any drugs or anything. I was so drugged I couldn’t make a cup of coffee. It’s getting better now, but I didn’t take my morning dose.

I contacted my pdoc this morning. She said it’s my choice if I want to try to adjust to it or just remain on Haldol. I’m not sure what to do.

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I think @Leaf used to take it. Maybe she can offer some advice.

If it were me, I’d give it some time though.

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Thanks @everhopeful

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Saphris is very sedating. That’s why I took all mine at night. If I took it in the morning I wanted to go back to sleep. So I took all 20 mg at night. I would wake up good though. It may take some time to adjust or it may be too strong for you. You’ll have to decide what you can tolerate.

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Zmgal I’ve tried various antipsychotics that came with various side effects. You shouldnt judge the saphris for one bad night. If you have patient with the saphris for some months and don’t give.up on it you will be rewarded with a pot of gold at the end of the rainbow. I thought for many years that 2. gen antipsychotics were use less. But I have finally realized that the 900 mgs Seroquel help me tremendiosly in my current life situation I’ve been on it for 12 years and I’ve now found a dose that suits me well

Thanks @Leaf. I’ve tried many APs. The only other one that was super sedating was Seroquel. I’m going to try it a little longer to see if I adjust to it.!?

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Looks like ase is about as sedating as Olanzapine which I would think is one of the more sedating medications.

That said each medication is going to act differently in it’s binding to profile dopamine and histamine receptors which cause sedation. Individual response is also a big thing

Everytime I try a new medication it hits me like a truck. I think that you build tolerance to the sedation overtime. When I first started taking latuda it knocked me out and I slept like a baby. Now I can take it and stay awake and not even notice the effects of sedation. I personally feel like you can build tolerance long term.

Alternatively a dosage reduction might be in order if symptoms are under control. If you get exacerbation of symptoms under a reduced dose you can always increase or swap.

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Maybe you could ask to try just taking 10mg at night. The half life is aprox. 24 hours, so it could still have a effect through the day.

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Give it a time @LilyoftheValley.
It’s good that it’s sedating, you’ll get used to not be “stoned”

It’s similar with clozapine, and sedation went with time.

I just wish best for you, I know your struggles.

Hugs.

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Give it some more time if you can @LilyoftheValley

Zyprexa made me feel stoned for a couple of days until I adjusted to it

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Thanks for the info @AmICrazyYet. I appreciate it

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Please stay brave don’t give up on saphris it’s one of the better antipsychotics out there. Most side effects vanishes in time.

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@Mr_Hope I’m taking 5 mg twice a day of asenapine, and went down to 10 mg from 15 of Haldol. Thanks though. I appreciate your input

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Thanks so much @anon82938303 :slight_smile:

Ok @Wave ill give it a go.

Thanks @columbus ive decided to stick with it a little longer just in case it helps

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