Trazodone helps with sexual dysfunction

lesterwaynedobo · April 22, 2014, 9:29pm

ncbi.nlm.nih.gov

Trazodone for the treatment of sexual dysfunction induced by serotonin reuptake inhibitors: a preliminary open-label study.

R Stryjer, B Spivak, RD Strous, R Shiloh, E Harary, L Polak, M Birgen, M Kotler and A Weizman, Clinical neuropharmacology, Mar-Apr 2009

Treatment with selective serotonin reuptake inhibitors (SSRIs) may lead to sexual dysfunction in up to 70% of patients. Because the SSRIs are widely used antidepressants, their propensity to cause sexual dysfunction may affect compliance with therapy and ultimately treatment success. To date, the pathophysiological mechanism of sexual dysfunction caused by SSRIs remains incompletely understood, and the management of SSRIs-induced sexual dysfunction remains unsatisfactory. We suggest that medications that antagonize serotonin receptors such as trazodone may improve sexual dysfunction reverting the stimulation of serotonin receptors by SSRIs.The aim of this study was to investigate the efficacy of trazodone administration in the management of SSRI-induced sexual dysfunction.Twenty patients (11 men/9 women) with SSRIs-induced sexual dysfunction were recruited for the study. Trazodone was added to the existing SSRI regimen in open-label fashion for 4 weeks (50 mg for the first week increased to 100 mg until the completion of the study). The improvement in the 4 dimensions of sexual function (desire, erection or lubrication problems in women, ejaculation or orgasm in women, and overall satisfaction by both sexes) was the primary outcome measure of the study.Fifteen subjects completed the study. Results indicated improvement in sexual function and overall clinical improvement (depression, anxiety) as well. Specific gender differences indicated improvement in erectile performance in men and lubrication in women. No correlations were noted between clinical improvement of depression or anxiety and improvement in sexual dysfunction.The 5-HT2 antagonist, trazodone, may be beneficial in the management of SSRI-induced sexual dysfunction. Large-scale, placebo-controlled, double-blind studies with 5-HT2 antagonists are required to substantiate these preliminary observations.

Jayster · April 23, 2014, 3:42am

My understanding is that Trazodone increases the ability to have sex but decreases the desire to do so.

What I want to know is whether or not these side effects of Trazodone are dose related.

Jayster

justinsg · April 23, 2014, 3:07pm

Im on Trazodone. It makes me sleep lots, even though I didn’t have any sleeping problems to begin with.

Sarah123 · May 7, 2014, 5:44pm

I’m on trazodone to help with sleeping, I didn’t know it did that as well

lesterwaynedobo · May 7, 2014, 7:52pm

When I take trazodone I usually wake up with morning wood. But when I use klonopin to aid sleep (which it does a great job) limp biscuit

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Trazodone helps with sexual dysfunction

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