[The association of serum folate levels with schizophrenia symptoms]

In patients, folate levels are inversely correlated with the severity of most negative symptoms and directly correlated with all measures of cognitive functions


I take the following supplement which is B12 + Folate.

I heared from schizophrenia help on youtube, that L-methylfolate is preferred.

L-methylfolate is a variation of B9 that doesn’t need to undergo enzymatic reduction to become biologically active.

So far I don’t see a positive effect from my supplement but it tastes good and sweet.
I did not get my blood serum levels for folate tested.


I tried methyl folate. And regular folic acid. No luck for me


I tried 5-methylfolate as an addon to escitalopram to my depression. I felt much better on it, but developed a severe allergy.

After that, I bought an ampoule of folinic acid, which acts similarly, bypassing the FOLR1 receptor to go straight into the cerebrospinal fluid. But I was too afraid to self-inject it, fearing allergy.

The basis for folinic acid treatment in neuro-psychiatric disorders

In contrast, in infantile autism and intractable schizophrenia, abnormal behavioral signs and symptoms may wax and wane with fluctuating FRα antibody titers over time accompanied by cycling changes in CSF folate, tetrahydrobiopterin (BH4) and neurotransmitter metabolites ranging between low and normal levels. We propose a hypothetical model explaining the pathogenesis of schizophrenia.


As always, “the dose makes the poison”.

# High folic acid supplementation associated with higher rates of COVID-19 infections and mortality

People in the United Kingdom with folic acid prescriptions were 1.5 times more likely to get COVID-19. They were also 2.6 times more likely to die from COVID-19 compared to the control group. Those are the findings of a new study from UC Davis Health and the University of Alabama at Birmingham.

The research, published in the journal BMJ Open , also found that having a prescription for the antifolate drug methotrexate mitigated the negative impact of folic acid on COVID-19 when folic acid and methotrexate were given together.

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