Although second-generation antipsychotic agents have mixed effects on neurotransmitters, they do affect serotonin systems. Abnormalities in these systems have been associated with violent behavior in a number of populations.
study patients taking clozapine had lower urgency ratings on the UPPS-P than patients taking other medications.
an important literature is emerging on the role of persecutory delusions in aggression in schizophrenia
The current article focuses on impulsive aggression. The recent finding that urgency plays a special role in aggression in schizophrenia suggests several novel approaches to better understand and treat these dysfunctional behaviors, and these approaches may have utility for other problematic behaviors associated with urgency, as well.